Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8181651 | 0.95 | PRKCI (0.48) | PRKCIALDH1A1KDM4EHSD17B10LMNA | |
| SCHEMBL8178110 | 0.92 | PRKCI (0.47) | PRKCIALDH1A1KDM4EHSD17B10LMNA | |
| SCHEMBL8180183 | 0.90 | ALDH1A1 (0.43) | ALDH1A1KDM4ELMNATHRBCYP1A2 | |
| SCHEMBL8171150 | 0.89 | LMNA (0.43) | ALDH1A1HSD17B10LMNATHRBCYP1A2 | |
| SCHEMBL8180756 | 0.88 | LMNA (0.43) | ALDH1A1LMNATHRBCYP1A2CYP3A4 | |
| SCHEMBL7609419 | 0.88 | PRKCI (0.64) | PRKCIALDH1A1KDM4EHSD17B10CNR2 | |
| SCHEMBL8184670 | 0.86 | PRKCI (0.47) | PRKCIALDH1A1KDM4EHSD17B10LMNA | |
| SCHEMBL8181999 | 0.86 | PDE5A (0.52) | PRKCIALDH1A1KDM4EHSD17B10LMNA | |
| SCHEMBL8179775 | 0.86 | LMNA (0.41) | ALDH1A1LMNATHRBCYP1A2CYP3A4 | |
| SCHEMBL8185149 | 0.85 | PRKCI (0.55) | PRKCIALDH1A1KDM4EHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |