Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | MRE11 | P49959 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | XDH | P47989 | 3/20 | 0.62 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.55 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | CLK2 | P49760 | 1/20 | 0.53 |
| ▸ | CLK3 | P49761 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 6/20 | 0.53 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8185403 | 1.00 | MEN1 (0.71) | MEN1KMT2AMRE11POLBXDH | |
| SCHEMBL8001437 | 0.86 | AKR1B1 (0.71) | AKR1B1PIM1PIM2PIM3HPGD | |
| SCHEMBL8001434 | 0.86 | AKR1B1 (0.71) | AKR1B1PIM1PIM2PIM3HPGD | |
| SCHEMBL15332601 | 0.85 | MEN1 (0.73) | MEN1KMT2AMRE11POLBXDH | |
| SCHEMBL15332599 | 0.85 | MEN1 (0.73) | MEN1KMT2AMRE11POLBXDH | |
| Mirin SCHEMBL21296287 | 0.83 | MRE11 (1.00) | MEN1KMT2AMRE11POLBXDH | |
| Mirin SCHEMBL15421605 | 0.83 | MRE11 (1.00) | MEN1KMT2AMRE11POLBXDH | |
| Mirin SCHEMBL15421606 | 0.83 | MRE11 (1.00) | MEN1KMT2AMRE11POLBXDH | |
| SCHEMBL22971852 | 0.83 | XDH (0.75) | MEN1KMT2AMRE11POLBXDH | |
| SCHEMBL23094478 | 0.80 | CISD1 (0.73) | MEN1KMT2AMRE11POLBXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |