Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.74 |
| ▸ | PIM1 | P11309 | 1/20 | 0.74 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.74 |
| ▸ | RAB9A | P51151 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | MYC | P01106 | 1/20 | 0.67 |
| ▸ | MAX | P61244 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 14/20 | 0.65 |
| ▸ | PNP | P00491 | 1/20 | 0.65 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8185473 | 1.00 | IGF1R (0.74) | IGF1RPIM1PIM2RAB9AMEN1 | |
| SCHEMBL8172752 | 0.86 | MYC (0.73) | IGF1RPIM1PIM2RAB9AMEN1 | |
| SCHEMBL8172749 | 0.86 | MYC (0.73) | IGF1RPIM1PIM2RAB9AMEN1 | |
| SCHEMBL2539569 | 0.85 | PIM1 (1.00) | IGF1RPIM1PIM2RAB9AHPGD | |
| SCHEMBL2539573 | 0.85 | PIM1 (1.00) | IGF1RPIM1PIM2RAB9AHPGD | |
| SCHEMBL2539566 | 0.85 | PIM1 (1.00) | IGF1RPIM1PIM2RAB9AHPGD | |
| SCHEMBL8172523 | 0.83 | HPGD (0.59) | IGF1RPIM1PIM2RAB9AMEN1 | |
| SCHEMBL8172525 | 0.83 | HPGD (0.59) | IGF1RPIM1PIM2RAB9AMEN1 | |
| SCHEMBL8186903 | 0.82 | TDP1 (0.61) | PIM1PIM2RAB9AMEN1ALDH1A1 | |
| SCHEMBL8186906 | 0.82 | TDP1 (0.61) | PIM1PIM2RAB9AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |