SCHEMBL818630

SCHEMBL818630

CC(Cl)C(Cl)(Cl)[C](Cl)Cl

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9002288 0.75
SCHEMBL11204495 0.75
SCHEMBL1979064 0.69
SCHEMBL1707413 0.69
SCHEMBL16970202 0.69
SCHEMBL27861307 0.67 ALDH1A1 (0.39)
SCHEMBL1087041 0.67
SCHEMBL204394 0.67
SCHEMBL27401445 0.67
SCHEMBL562402 0.65

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5262420-A Phenylalkylpyridines IDEMITSU KOSAN CO., LTD. (JP) 1993-11-16 US claimed
EP-3682873-B1 SMAC MIMETICS FOR USE IN THE TREATMENT OF PERSISTENT HIV INFECTION WALTER & ELIZA HALL INST MEDICAL RES (AU) 2024-06-12 EP disclosed
US-11702401-B2 Compounds and methods of use MEDIVATION TECHNOLOGIES LLC (US) 2023-07-18 US disclosed
US-20220000847-A1 Compounds and Methods of Use MEDIVATION TECHNOLOGIES LLC (US) 2022-01-06 US disclosed
US-11053216-B2 Compounds and methods of use MEDIVATION TECHNOLOGIES LLC (US) 2021-07-06 US disclosed
CN-112957365-A Methods of treating intracellular infections 沃尔特和伊利莎豪医学研究所 2021-06-15 CN disclosed
CN-105451726-B Methods of treating intracellular infections 沃尔特和伊利莎豪医学研究所 2021-03-16 CN disclosed
EP-3013329-B1 SMAC MIMETICS FOR THE TREATMENT OF PERSISTENT INTRACELLULAR HBV INFECTION WALTER & ELIZA HALL INST MEDICAL RES (AU) 2020-08-05 EP disclosed
CN-111481669-A Methods of treating intracellular infections 沃尔特和伊利莎豪医学研究所 2020-08-04 CN disclosed
EP-3089971-B1 COMPOUNDS AND METHODS OF USE MEDIVATION TECH LLC (US) 2020-07-29 EP disclosed
WO-2006056873-A2 THERAPEUTIC PYRAZOLO[3,4-B] PYRIDINES AND INDAZOLES WARNER-LAMBERT COMPANY LLC (US) 2006-06-01 WO disclosed
WO-2006003500-A1 METHOD FOR PREPARING 5-`4-(2-HYDROXY-PROPYL)-3,5-DIOXO-4,5-DIHYDRO-3H`1,2,4!TRIAZIN-2-YL!-BENZAMIDE DERIVATIVES BY DEPROTECTING THE HYDROXYL-PROTECTED PRECURSERS PFIZER PRODUCTS INC. (US) 2006-01-12 WO disclosed
WO-2006003513-A1 METHOD FOR PREPARING 5-`4-(2-HYDROXY-ETHYL)-3,5-DIOXO-4,5-DIHYDRO-3H-`1,2,4!-TRIAZIN-2-YL!BENZAMIDE DERIVATIVES WITH P2X7 INHIBITING ACTIVITY BY REACTION OF THE DERIVATIVE UNSUBSTITUTED IN 4-POSITION OF THE TRIAZINE WITH AN OXIRAN IN THE PRESENCE OF A LEWIS ACID PFIZER PRODUCTS INC. (US) 2006-01-12 WO disclosed
US-20050288256-A1 Methods for preparing P2X7 inhibitors PFIZER INC. 2005-12-29 US disclosed
US-20050288288-A1 Methods for preparing P2X7 inhibitors PFIZER INC. 2005-12-29 US disclosed
WO-2005105801-A1 PYRROLYL SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7-ONES AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS WARNER-LAMBERT COMPANY LLC (US) 2005-11-10 WO disclosed
EP-1586564-A1 8-AZAPROSTAGLANDIN DERIVATIVES AND MEDICINAL USES THEREOF ONO PHARMACEUTICAL CO., LTD. (JP) 2005-10-19 EP disclosed
WO-2005042519-A1 PYRIMIDINES AS INHIBITORS OF PHOSPHOINOSITIDE -3-KINASES (PI3K) WARNER-LAMBERT COMPANY LLC (US) 2005-05-12 WO disclosed
US-5262420-A Phenylalkylpyridines IDEMITSU KOSAN CO., LTD. (JP) 1993-11-16 US disclosed
EP-0383950-A1 PYRIDINE DERIVATIVES AND INSECTICIDAL AND MITICIDAL AGENT CONTAINING SAME AS ACTIVE INGREDIENT IDEMITSU KOSAN COMPANY LIMITED (JP) 1990-08-29 EP disclosed