Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Alatrofloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | HPGD | P15428 | 3/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | XBP1 | P17861 | 1/20 | 0.73 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.73 |
| ▸ | HTT | P42858 | 1/20 | 0.73 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.73 |
| ▸ | RELA | Q04206 | 1/20 | 0.73 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.65 |
| ▸ | FLT4 | P35916 | 1/20 | 0.65 |
| ▸ | GSK3B | P49841 | 1/20 | 0.65 |
| ▸ | RARB | P10826 | 1/20 | 0.65 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | DPP4 | P27487 | 6/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alatrofloxacin SCHEMBL41134 | 1.00 | LMNA (0.73) | LMNAKDM4EHSD17B10ALDH1A1HPGD | |
| Alatrofloxacin SCHEMBL29389843 | 1.00 | LMNA (0.73) | LMNAKDM4EHSD17B10ALDH1A1HPGD | |
| Alatrofloxacin SCHEMBL7616277 | 0.97 | EPHA2 (0.69) | LMNAKDM4EHSD17B10ALDH1A1HPGD | |
| Alatrofloxacin SCHEMBL7618000 | 0.97 | EPHA2 (0.69) | LMNAKDM4EHSD17B10ALDH1A1HPGD | |
| Alatrofloxacin SCHEMBL29493446 | 0.97 | EPHA2 (0.69) | LMNAKDM4EHSD17B10ALDH1A1HPGD | |
| Alatrofloxacin SCHEMBL140567 | 0.97 | EPHA2 (0.69) | LMNAKDM4EHSD17B10ALDH1A1HPGD | |
| Alatrofloxacin SCHEMBL7101443 | 0.97 | EPHA2 (0.69) | LMNAKDM4EHSD17B10ALDH1A1HPGD | |
| Alatrofloxacin SCHEMBL28214885 | 0.94 | EPHA2 (0.75) | LMNAKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL6848316 | 0.94 | EPHA2 (0.65) | LMNAKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL9735079 | 0.92 | EPHA2 (0.74) | LMNAKDM4EHSD17B10ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000086-A1 | ALATROFLOXACIN PARENTERAL COMPOSITIONS | Pfizer Products Inc. (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999006430-A1 | ALATROFLOXACIN PARENTERAL COMPOSITIONS | PFIZER PRODUCTS INC. (US) | 1999-02-11 | — | — | WO | disclosed |