Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | OGFRL1 | Q5TC84 | 4/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8192426 | 0.99 | PDE4A (0.46) | PDE4AKMT2AOGFRL1OPRM1OPRK1 | |
| SCHEMBL8191337 | 0.98 | PDE4A (0.47) | PDE4AKMT2AOGFRL1OPRM1OPRK1 | |
| SCHEMBL8191382 | 0.96 | PDE4A (0.48) | PDE4AKMT2AOGFRL1OPRM1OPRK1 | |
| SCHEMBL8177229 | 0.89 | KMT2A (0.40) | PDE4AKMT2AHTR2CALDH1A1POLB | |
| SCHEMBL8189529 | 0.88 | KMT2A (0.39) | PDE4AKMT2AHTR2CALDH1A1POLB | |
| SCHEMBL8187166 | 0.86 | HTR2C (0.36) | PDE4AKMT2AHTR2CALDH1A1POLB | |
| SCHEMBL8186875 | 0.85 | KMT2A (0.36) | KMT2AOPRK1HTR2CALDH1A1POLB | |
| SCHEMBL8177219 | 0.84 | HTR2C (0.39) | PDE4AKMT2AOGFRL1OPRM1OPRK1 | |
| SCHEMBL8245208 | 0.82 | HTR2C (0.39) | PDE4AKMT2AHTR2CALDH1A1POLB | |
| SCHEMBL6627867 | 0.81 | KDM4E (0.51) | KMT2AOGFRL1OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-10218881-A | — | — | None | — | — | JP | disclosed |
| US-6057330-A | USEFUL FOR THE PREVENTION AND TREATMENT OF A RESPIRATORY DISEASES REPRESENTED BY ASTHMA | POLA CHEMICAL INDUSTRIES, INC. (JP) | 2000-05-02 | — | — | US | disclosed |
| JP-H10218881-A | NEW PYRROLOPYRAZOLOPYRIMIDINE DERIVATIVE | POLA CHEM IND INC | 1998-08-18 | — | — | JP | disclosed |