Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | HTR2B | P41595 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 5/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8177219 | 0.98 | HTR2C (0.39) | HTR2CHTR2AHTR2BKMT2AKDM4E | |
| SCHEMBL8177229 | 0.84 | KMT2A (0.40) | HTR2CHTR2AHTR2BKMT2AKDM4E | |
| SCHEMBL8191337 | 0.84 | PDE4A (0.47) | HTR2CKMT2AKDM4EALDH1A1POLB | |
| SCHEMBL8189529 | 0.83 | KMT2A (0.39) | HTR2CHTR2AHTR2BKMT2AKDM4E | |
| SCHEMBL8187166 | 0.82 | HTR2C (0.36) | HTR2CHTR2AHTR2BKMT2AKDM4E | |
| SCHEMBL8187118 | 0.82 | PDE4A (0.47) | HTR2CKMT2AKDM4EALDH1A1POLB | |
| SCHEMBL8186875 | 0.81 | KMT2A (0.36) | HTR2CHTR2AHTR2BKMT2AKDM4E | |
| SCHEMBL8192426 | 0.81 | PDE4A (0.46) | HTR2CKMT2AALDH1A1POLBMAPT | |
| SCHEMBL8176828 | 0.80 | HTR2C (0.41) | HTR2CHTR2AHTR2BKMT2AKDM4E | |
| SCHEMBL8191382 | 0.79 | PDE4A (0.48) | HTR2CKMT2AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021447-A1 | PYRROLOPYRAZOLOPYRIMIDINE COMPOUND AND MEDICINE COMPRISING THE SAME | POLA CHEMICAL INDUSTRIES, INC. (JP) | 2000-07-26 | — | — | EP | disclosed |
| WO-1998033799-A1 | PYRROLOPYRAZOLOPYRIMIDINE COMPOUND AND MEDICINE COMPRISING THE SAME | POLA CHEMICAL INDUSTRIES, INC. (JP) | 1998-08-06 | — | — | WO | disclosed |