Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8182681 | 0.84 | MALT1 (0.47) | MALT1IDO1PDCD1CD274PDK2 | |
| SCHEMBL29717117 | 0.84 | GAA (0.54) | MALT1ALDH1A1GAAPOLBKDM4E | |
| SCHEMBL26667473 | 0.84 | GAA (0.54) | MALT1ALDH1A1GAAPOLBKDM4E | |
| SCHEMBL24302720 | 0.84 | GAA (0.54) | MALT1ALDH1A1GAAPOLBKDM4E | |
| SCHEMBL8188900 | 0.83 | MALT1 (0.47) | MALT1IDO1PDCD1CD274PDK2 | |
| SCHEMBL29323153 | 0.80 | MALT1 (0.47) | MALT1IDO1MAPK1PDCD1CD274 | |
| SCHEMBL4392860 | 0.78 | MALT1 (0.49) | MALT1IDO1PDK2SMN1; SMN2BCHE | |
| SCHEMBL8182878 | 0.78 | GAA (0.48) | MALT1ALDH1A1GAAPOLBKDM4E | |
| SCHEMBL8182883 | 0.78 | GAA (0.48) | MALT1ALDH1A1GAAPOLBKDM4E | |
| SCHEMBL26931811 | 0.77 | MALT1 (0.49) | MALT1GAAIDO1PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000044731-A1 | NOVEL HYDROXYAMIDINO CARBOXYLATE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-08-03 | — | — | WO | disclosed |