Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8187531 | 0.91 | KDM4E (0.34) | ALDH1A1L3MBTL1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL8185115 | 0.89 | KDM4E (0.39) | ALDH1A1L3MBTL1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL8185635 | 0.84 | POLB (0.41) | ALDH1A1L3MBTL1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL8177617 | 0.81 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL6628015 | 0.79 | KDM4E (0.49) | ALDH1A1POLBKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL8185997 | 0.79 | KDM4E (0.45) | ALDH1A1L3MBTL1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL8191815 | 0.79 | KDM4E (0.33) | ALDH1A1L3MBTL1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL8191383 | 0.78 | HTR2A (0.34) | ALDH1A1L3MBTL1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL8186151 | 0.78 | KDM4E (0.34) | ALDH1A1L3MBTL1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL8186064 | 0.77 | ALDH1A1 (0.36) | ALDH1A1L3MBTL1POLBKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021447-A1 | PYRROLOPYRAZOLOPYRIMIDINE COMPOUND AND MEDICINE COMPRISING THE SAME | POLA CHEMICAL INDUSTRIES, INC. (JP) | 2000-07-26 | — | — | EP | disclosed |
| US-6057330-A | USEFUL FOR THE PREVENTION AND TREATMENT OF A RESPIRATORY DISEASES REPRESENTED BY ASTHMA | POLA CHEMICAL INDUSTRIES, INC. (JP) | 2000-05-02 | — | — | US | disclosed |
| US-5942515-A | RESPIRATORY SYSTEM DISORDERS | POLA CHEMICAL INDUSTRIES, INC. (JP) | 1999-08-24 | — | — | US | disclosed |
| WO-1998033799-A1 | PYRROLOPYRAZOLOPYRIMIDINE COMPOUND AND MEDICINE COMPRISING THE SAME | POLA CHEMICAL INDUSTRIES, INC. (JP) | 1998-08-06 | — | — | WO | disclosed |