Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 7/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | AGXT | P21549 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | UGCG | Q16739 | 1/20 | 0.37 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8188326 | 1.00 | TDP1 (0.43) | TDP1L3MBTL1CA1CA2APP | |
| SCHEMBL8188328 | 1.00 | TDP1 (0.43) | TDP1L3MBTL1CA1CA2APP | |
| SCHEMBL8184404 | 0.85 | APP (0.45) | TDP1L3MBTL1CA1CA2APP | |
| SCHEMBL8184408 | 0.85 | APP (0.45) | TDP1L3MBTL1CA1CA2APP | |
| SCHEMBL8184411 | 0.85 | APP (0.45) | TDP1L3MBTL1CA1CA2APP | |
| SCHEMBL8184477 | 0.79 | L3MBTL1 (0.36) | TDP1L3MBTL1CA1CA2APP | |
| SCHEMBL8184474 | 0.79 | L3MBTL1 (0.36) | TDP1L3MBTL1CA1CA2APP | |
| SCHEMBL8184472 | 0.79 | L3MBTL1 (0.36) | TDP1L3MBTL1CA1CA2APP | |
| SCHEMBL18031454 | 0.77 | F2RL1 (0.50) | TDP1L3MBTL1CA1CA2APP | |
| SCHEMBL8176151 | 0.77 | TDP1 (0.47) | TDP1L3MBTL1CA1CA2APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6017923-A | Carbo-acyclic nucleoside derivatives as antiviral and antineoplastic agents | HOECHST MARION ROUSSEL, INC. (US) | 2000-01-25 | — | — | US | disclosed |
| EP-0705264-B1 | CARBO-ACYCLIC NUCLEOSIDE DERIVATIVES AS ANTIVIRAL AND ANTINEOPLASTIC AGENTS | MERRELL PHARMA INC (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1995000515-A1 | CARBO-ACYCLIC NUCLEOSIDE DERIVATIVES AS ANTIVIRAL AND ANTINEOPLASTIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-01-05 | — | — | WO | disclosed |