Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 4/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8192279 | 0.95 | AGTR1 (0.39) | AGTR1AGTR2MPO | |
| SCHEMBL8190892 | 0.93 | AGTR1 (0.39) | AGTR1AGTR2MPO | |
| SCHEMBL8190205 | 0.91 | AGTR1 (0.38) | AGTR1AGTR2MPO | |
| SCHEMBL7339320 | 0.90 | AGTR1 (0.41) | AGTR1AGTR2MPO | |
| SCHEMBL8193197 | 0.89 | AGTR1 (0.40) | AGTR1AGTR2MPO | |
| SCHEMBL7334860 | 0.88 | AGTR1 (0.40) | AGTR1AGTR2MPO | |
| SCHEMBL9739375 | 0.88 | AGTR1 (0.49) | AGTR1AGTR2 | |
| SCHEMBL8187711 | 0.87 | AGTR1 (0.37) | AGTR1AGTR2 | |
| SCHEMBL7334890 | 0.87 | AGTR1 (0.40) | AGTR1AGTR2 | |
| SCHEMBL8190185 | 0.87 | AGTR1 (0.39) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090828-A | ARTHERIOSCLEROSIS | REITZ DAVID B (US) | 2000-07-18 | — | — | US | disclosed |
| US-5451593-A | Method of using 5-arylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of a glaucoma disorder | G. D. SEARLE & CO. (US) | 1995-09-19 | — | — | US | disclosed |
| WO-1992016523-A1 | 5-ARYLHETEROARYLALKYL-1,3,5-TRISUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-10-01 | — | — | WO | disclosed |