Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 13/20 | 0.70 |
| ▸ | TDP2 | O95551 | 1/20 | 0.60 |
| ▸ | IGF1R | P08069 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | PNP | P00491 | 1/20 | 0.51 |
| ▸ | NAT1 | P18440 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8189590 | 1.00 | TDP1 (0.70) | TDP1TDP2IGF1RMEN1KMT2A | |
| SCHEMBL14860944 | 0.82 | TDP1 (1.00) | TDP1TDP2PNPNAT1 | |
| SCHEMBL14860946 | 0.82 | TDP1 (1.00) | TDP1TDP2PNPNAT1 | |
| SCHEMBL14860947 | 0.82 | TDP1 (1.00) | TDP1TDP2PNPNAT1 | |
| SCHEMBL15347653 | 0.82 | NAT1 (0.76) | IGF1RMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8193225 | 0.82 | NAT1 (0.76) | IGF1RMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8193222 | 0.82 | NAT1 (0.76) | IGF1RMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8182123 | 0.77 | TDP1 (1.00) | TDP1IGF1RMEN1KMT2AALDH1A1 | |
| SCHEMBL8182124 | 0.77 | TDP1 (1.00) | TDP1IGF1RMEN1KMT2AALDH1A1 | |
| SCHEMBL14860898 | 0.77 | TDP1 (1.00) | TDP1IGF1RMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |