Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | MC5R | P33032 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9127039 | 0.83 | SIGMAR1 (0.56) | SIGMAR1CYP1A2GRIN2DGRIN2AGRIN2B | |
| SCHEMBL18951598 | 0.83 | GRIN2D (0.62) | SIGMAR1CYP1A2GRIN2DGRIN2AGRIN2B | |
| SCHEMBL14402515 | 0.79 | SIGMAR1 (0.51) | SIGMAR1CYP1A2GRIN2DGRIN2AGRIN2B | |
| SCHEMBL13849329 | 0.79 | SIGMAR1 (0.51) | SIGMAR1CYP1A2GRIN2DGRIN2AGRIN2B | |
| SCHEMBL6569353 | 0.79 | TSHR (0.47) | SIGMAR1HDAC1HDAC8 | |
| SCHEMBL9126634 | 0.79 | SIGMAR1 (0.54) | SIGMAR1CYP1A2GRIN2DGRIN2AGRIN2B | |
| SCHEMBL15178309 | 0.77 | SIGMAR1 (0.53) | SIGMAR1CYP1A2GRIN2DGRIN2AGRIN2B | |
| SCHEMBL9128987 | 0.77 | SIGMAR1 (0.53) | SIGMAR1CYP1A2GRIN2DGRIN2AGRIN2B | |
| SCHEMBL9127853 | 0.77 | SIGMAR1 (0.53) | SIGMAR1CYP1A2GRIN2DGRIN2AGRIN2B | |
| SCHEMBL17979637 | 0.77 | SIGMAR1 (0.49) | SIGMAR1CYP1A2GRIN2DGRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1011650-A1 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | Amgen Inc., (US) | 2000-06-28 | — | — | EP | disclosed |
| WO-1999014998-A2 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | AMGEN INC. (US) | 1999-04-01 | — | — | WO | disclosed |