Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8189803 | 0.96 | KMT2A (0.58) | KMT2AMEN1TSHRALDH1A1L3MBTL1 | |
| SCHEMBL11892987 | 0.85 | KMT2A (0.55) | KMT2AMEN1TSHRALDH1A1L3MBTL1 | |
| SCHEMBL6663904 | 0.85 | KMT2A (0.57) | KMT2AMEN1TSHRALDH1A1L3MBTL1 | |
| SCHEMBL6905958 | 0.85 | KMT2A (0.57) | KMT2AMEN1TSHRALDH1A1L3MBTL1 | |
| SCHEMBL12468980 | 0.81 | MEN1 (0.53) | KMT2AMEN1TSHRALDH1A1KDM4E | |
| SCHEMBL13808520 | 0.80 | ALDH1A1 (0.55) | KMT2AMEN1TSHRALDH1A1L3MBTL1 | |
| SCHEMBL10947749 | 0.80 | KMT2A (0.76) | KMT2AMEN1TSHRALDH1A1L3MBTL1 | |
| SCHEMBL3394990 | 0.79 | HSD17B10 (0.56) | KMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL3394995 | 0.79 | HSD17B10 (0.56) | KMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL14212456 | 0.79 | MEN1 (0.50) | KMT2AMEN1TSHRALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156752-A | Optically active 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC (US) | 2000-12-05 | — | — | US | disclosed |
| EP-0899261-A1 | Optical active 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC. (US) | 1999-03-03 | — | — | EP | disclosed |