Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 8/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 8/20 | 0.57 |
| ▸ | BLM | P54132 | 7/20 | 0.57 |
| ▸ | USP2 | O75604 | 6/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.57 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 8/20 | 0.54 |
| ▸ | MAPT | P10636 | 8/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.54 |
| ▸ | CDC25A | P30304 | 7/20 | 0.54 |
| ▸ | CDC25B | P30305 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | THRB | P10828 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | APEX1 | P27695 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8190582 | 1.00 | POLB (0.57) | POLBL3MBTL1MCL1BLMUSP2 | |
| SCHEMBL5139089 | 0.80 | MEN1 (0.59) | POLBL3MBTL1MCL1BLMHPGD | |
| SCHEMBL5139092 | 0.80 | MEN1 (0.59) | POLBL3MBTL1MCL1BLMHPGD | |
| SCHEMBL5139091 | 0.80 | MEN1 (0.59) | POLBL3MBTL1MCL1BLMHPGD | |
| SCHEMBL8173854 | 0.79 | POLB (0.44) | POLBL3MBTL1MCL1BLMUSP2 | |
| SCHEMBL8173851 | 0.79 | POLB (0.44) | POLBL3MBTL1MCL1BLMUSP2 | |
| SCHEMBL8171935 | 0.78 | NAT1 (0.63) | KMT2ACDC25BMEN1ALDH1A1RAB9A | |
| SCHEMBL8171937 | 0.78 | NAT1 (0.63) | KMT2ACDC25BMEN1ALDH1A1RAB9A | |
| SCHEMBL8181542 | 0.75 | F2 (0.56) | POLBL3MBTL1MCL1BLMUSP2 | |
| SCHEMBL8181543 | 0.75 | F2 (0.56) | POLBL3MBTL1MCL1BLMUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018748-A1 | RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |