Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.44 |
| ▸ | PDE4A | P27815 | 8/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415380 | 0.79 | HTT (0.76) | PDE5AALDH1A1HTTPDE4BPDE4D | |
| SCHEMBL7468318 | 0.75 | PDE4B (0.55) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL4402865 | 0.75 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL1388279 | 0.74 | PDE5A (0.60) | PDE5APDE4BPDE4DPDE4APDE4C | |
| SCHEMBL8484272 | 0.74 | MAPT (0.54) | PDE5AALDH1A1LMNAHTTPOLB | |
| SCHEMBL8484276 | 0.74 | MAPT (0.54) | PDE5AALDH1A1LMNAHTTPOLB | |
| SCHEMBL4407286 | 0.73 | PDE4A (0.51) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL8119187 | 0.73 | HTT (0.62) | PDE5AALDH1A1LMNAHTTPDE4B | |
| SCHEMBL7337371 | 0.73 | PDE5A (1.00) | PDE5AALDH1A1PDE4BPDE4DPDE4A | |
| SCHEMBL12923593 | 0.72 | PDE4B (0.58) | PDE4BPDE4DPDE4APDE4CPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6096747-A | Phenylaminocarbonyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-08-01 | — | — | US | disclosed |
| EP-0607373-B1 | TRISUBSTITUTED PHENYL DERIVATIVES AS SELECTIVE PHOSPHODIESTERASE IV INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 1997-03-19 | — | — | EP | disclosed |
| US-5550137-A | Phenylaminocarbonyl derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 1996-08-27 | — | — | US | disclosed |