Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.76 |
| ▸ | PDE5A | O76074 | 4/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.58 |
| ▸ | PDE4A | P27815 | 2/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.58 |
| ▸ | PDE1A | P54750 | 1/20 | 0.54 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.54 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415951 | 0.84 | POLB (0.64) | HTTPDE5APOLBPDE4DPDE4A | |
| SCHEMBL7413887 | 0.84 | PDE5A (0.67) | HTTPDE5APOLBPDE4DPDE4A | |
| SCHEMBL8748848 | 0.84 | PDE4D (0.67) | HTTPDE5APOLBPDE4DPDE4A | |
| SCHEMBL8188616 | 0.81 | PDE4D (0.63) | PDE5APOLBPDE4DPDE4APDE4B | |
| SCHEMBL7466774 | 0.81 | SETD7 (0.77) | HTTPDE5APOLBPDE4DPDE4A | |
| SCHEMBL4347187 | 0.80 | PDE4D (0.66) | PDE5APOLBPDE4DPDE4APDE4B | |
| SCHEMBL7423277 | 0.80 | PDE4D (0.78) | PDE5APOLBPDE4DPDE4APDE4B | |
| SCHEMBL7337371 | 0.80 | PDE5A (1.00) | PDE5APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8190859 | 0.79 | PDE5A (0.57) | HTTPDE5APOLBPDE4DPDE4A | |
| SCHEMBL9526886 | 0.78 | PDE5A (0.83) | PDE5APDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6096747-A | Phenylaminocarbonyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-08-01 | — | — | US | claimed |
| EP-0607373-B1 | TRISUBSTITUTED PHENYL DERIVATIVES AS SELECTIVE PHOSPHODIESTERASE IV INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 1997-03-19 | — | — | EP | claimed |
| EP-0607373-A1 | TRISUBSTITUTED PHENYL DERIVATIVES AS SELECTIVE PHOSPHODIESTERASE IV INHIBITORS. | CELLTECH LTD (GB) | 1994-07-27 | — | — | EP | claimed |
| WO-1993025517-A1 | TRISUBSTITUTED PHENYL DERIVATIVES AS SELECTIVE PHOSPHODIESTERASE IV INHIBITORS | CELLTECH LIMITED (GB) | 1993-12-23 | — | — | WO | claimed |
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |
| US-6096747-A | Phenylaminocarbonyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-08-01 | — | — | US | disclosed |
| EP-0607373-B1 | TRISUBSTITUTED PHENYL DERIVATIVES AS SELECTIVE PHOSPHODIESTERASE IV INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 1997-03-19 | — | — | EP | disclosed |
| US-5550137-A | Phenylaminocarbonyl derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 1996-08-27 | — | — | US | disclosed |
| EP-0607373-A1 | TRISUBSTITUTED PHENYL DERIVATIVES AS SELECTIVE PHOSPHODIESTERASE IV INHIBITORS. | CELLTECH LTD (GB) | 1994-07-27 | — | — | EP | disclosed |
| WO-1993025517-A1 | TRISUBSTITUTED PHENYL DERIVATIVES AS SELECTIVE PHOSPHODIESTERASE IV INHIBITORS | CELLTECH LIMITED (GB) | 1993-12-23 | — | — | WO | disclosed |