Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAN2A1 | Q16706 | 1/20 | 0.39 |
| ▸ | MAN1B1 | Q9UKM7 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 4/20 | 0.34 |
| ▸ | GFRA3 | O60609 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205004 | 1.00 | MAN2A1 (0.39) | MAN2A1MAN1B1USP2LMNAMAPT | |
| SCHEMBL8192532 | 1.00 | MAN2A1 (0.39) | MAN2A1MAN1B1USP2LMNAMAPT | |
| SCHEMBL8192529 | 1.00 | MAN2A1 (0.39) | MAN2A1MAN1B1USP2LMNAMAPT | |
| SCHEMBL8205006 | 1.00 | MAN2A1 (0.39) | MAN2A1MAN1B1USP2LMNAMAPT | |
| SCHEMBL8202278 | 0.78 | USP2 (0.46) | USP2MAPTMAPK1MEN1KMT2A | |
| SCHEMBL8202280 | 0.78 | USP2 (0.46) | USP2MAPTMAPK1MEN1KMT2A | |
| SCHEMBL8202272 | 0.78 | USP2 (0.46) | USP2MAPTMAPK1MEN1KMT2A | |
| SCHEMBL8204179 | 0.75 | CD274 (0.47) | — | |
| SCHEMBL8203683 | 0.75 | CD274 (0.47) | — | |
| SCHEMBL8203686 | 0.75 | CD274 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998036749-A1 | TETRALONE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-27 | — | — | WO | claimed |
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |