Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL820310 | 1.00 | KDM4E (0.34) | KDM4EALDH1A1MAPTGAACASP1 | |
| SCHEMBL818239 | 0.77 | HTR6 (0.49) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL823067 | 0.77 | HTR6 (0.49) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL12405713 | 0.76 | XIAP (0.40) | MEN1KMT2AEGFRMAPKAPK2 | |
| SCHEMBL820554 | 0.73 | MCL1 (0.35) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL820539 | 0.72 | HTR2A (0.35) | ALDH1A1MEN1KMT2AEGFRMAPKAPK2 | |
| SCHEMBL818116 | 0.72 | HTR2A (0.35) | ALDH1A1MEN1KMT2AEGFRMAPKAPK2 | |
| SCHEMBL820311 | 0.70 | DPP8 (0.37) | KDM4EALDH1A1MAPTGAACASP1 | |
| SCHEMBL818270 | 0.70 | DPP8 (0.37) | KDM4EALDH1A1MAPTGAACASP1 | |
| SCHEMBL1864140 | 0.69 | SMN1; SMN2 (0.62) | ALDH1A1MEN1KMT2ACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110288116-A1 | IAP INHIBITORS | TETRALOGIC PHARMACEUITCAL CORPORATION (US) | 2011-11-24 | — | — | US | disclosed |
| EP-2242362-A1 | IAP INHIBITORS | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009094287-A1 | IAP INHIBITORS | TETRALOGIC PHARMACEUTICAL CORPORATION (US) | 2009-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288116-A1 | IAP INHIBITORS | XIAP, BIRC5, BIRC7 | KDM4E 3168/4885ALDH1A1 4283/4885MAPT 1439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.