Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.35 |
| ▸ | ITGAV | P06756 | 3/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1220487 | 0.89 | PPARG (0.47) | PPARGCYP3A4RXRAHPGDHRH3 | |
| SCHEMBL8791594 | 0.87 | PPARG (0.41) | PPARGCYP3A4RXRAHPGDHRH3 | |
| SCHEMBL7839019 | 0.87 | PPARG (0.42) | PPARGCYP3A4RXRAHPGDHRH3 | |
| SCHEMBL8791799 | 0.84 | HPGD (0.54) | PPARGCYP3A4RXRAHPGDHRH3 | |
| SCHEMBL8792213 | 0.83 | PPARG (0.52) | PPARGCYP3A4RXRAHPGDHRH3 | |
| SCHEMBL9311838 | 0.82 | FFAR1 (0.43) | PPARGCYP3A4RXRAFFAR1 | |
| SCHEMBL8793769 | 0.82 | PPARG (0.41) | PPARGCYP3A4RXRAHPGDHRH3 | |
| SCHEMBL8196242 | 0.80 | PPARG (0.66) | PPARGCYP3A4RXRAHPGDFFAR1 | |
| SCHEMBL163917 | 0.80 | PPARG (0.66) | PPARGCYP3A4RXRAHPGDHRH3 | |
| Hydrochloric Acid SCHEMBL2944707 | 0.80 | PPARG (0.66) | PPARGCYP3A4RXRAHPGDHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0508740-B1 | Thiazolidinedione derivatives, their production and their use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-01 | — | — | EP | claimed |
| US-5183823-A | PYRIDINE N-OXIDE COMPOUNDS WHICH ARE USEFUL AS HYPOGLYCEMIC AND HYPOLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-02-02 | — | — | US | claimed |
| EP-0508740-A1 | Thiazolidinedione derivatives, their production and their use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-10-14 | — | — | EP | claimed |
| US-RE36575-E | Pyridine and thiazolidinedione derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-15 | — | — | US | disclosed |
| EP-0508740-B1 | Thiazolidinedione derivatives, their production and their use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-01 | — | — | EP | disclosed |
| US-5183823-A | PYRIDINE N-OXIDE COMPOUNDS WHICH ARE USEFUL AS HYPOGLYCEMIC AND HYPOLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-02-02 | — | — | US | disclosed |
| EP-0508740-A1 | Thiazolidinedione derivatives, their production and their use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-10-14 | — | — | EP | disclosed |
| EP-0257781-B1 | A METHOD FOR PRODUCING THIAZOLIDINEDIONE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 1991-09-18 | — | — | EP | disclosed |
| US-4898947-A | Pyridine and thiazolidinedione derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-02-06 | — | — | US | disclosed |
| US-4812570-A | Method for producing thiazolidinedione derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-03-14 | — | — | US | disclosed |