Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.72 |
| ▸ | GAA | P10253 | 4/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | HTT | P42858 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6752323 | 1.00 | MAPT (0.72) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL6748762 | 1.00 | MAPT (0.72) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL6748764 | 1.00 | MAPT (0.72) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL6752606 | 1.00 | MAPT (0.72) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL23355364 | 0.91 | MAPT (0.73) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL23355908 | 0.91 | MAPT (0.73) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL20639805 | 0.89 | MAPT (0.57) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL6944234 | 0.89 | MAPT (0.70) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL6939775 | 0.89 | MAPT (0.70) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL8445710 | 0.89 | MAPT (0.70) | MAPTGAAKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166018-A | 2R, 4S, R, S- and 2S, 4R, R, S-hydroxyitraconazole | SEPRACOR INC. (US) | 2000-12-26 | — | — | US | disclosed |