Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.72 |
| ▸ | GAA | P10253 | 4/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | HTT | P42858 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6752323 | 1.00 | MAPT (0.72) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL6748762 | 1.00 | MAPT (0.72) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL8196645 | 1.00 | MAPT (0.72) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL6752606 | 1.00 | MAPT (0.72) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL23355364 | 0.91 | MAPT (0.73) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL23355908 | 0.91 | MAPT (0.73) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL20639805 | 0.89 | MAPT (0.57) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL6944234 | 0.89 | MAPT (0.70) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL6939775 | 0.89 | MAPT (0.70) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL8445710 | 0.89 | MAPT (0.70) | MAPTGAAKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958289-B1 | AMINO ACID ESTER CONTAINING AZOLE ANTIFUNGALS | JANSSEN PHARMACEUTICA NV (BE) | 2004-06-30 | — | — | EP | disclosed |
| US-6703506-B2 | DIOXOLANE DERIVATIVES AND INTERMEDIATES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-03-09 | — | — | US | disclosed |
| US-20030158210-A1 | Amino acid ester containing azole antifungals | MEERPOEL LIEVEN (BE) | 2003-08-21 | — | — | US | disclosed |
| US-6512116-B2 | No drug resistance; intravenous | JANSSEN PHARMACEUTICA NV (BE) | 2003-01-28 | — | — | US | disclosed |
| US-6262052-B1 | Amino acid ester containing azole antifungals | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158210-A1 | Amino acid ester containing azole antifungals | DAO, SLC7A1, IL4I1 | MAPT 3961/4885GAA 2428/4885KDM4E 1361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.