Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7549974 | 0.89 | REN (0.75) | REN | |
| Hydrochloric Acid SCHEMBL6043408 | 0.89 | REN (0.74) | REN | |
| Hydrochloric Acid SCHEMBL7566598 | 0.86 | REN (0.90) | REN | |
| Trifluoroacetic Acid SCHEMBL6043100 | 0.86 | REN (0.81) | REN | |
| SCHEMBL7549811 | 0.85 | REN (1.00) | REN | |
| Trifluoroacetic Acid SCHEMBL6043069 | 0.84 | REN (0.84) | REN | |
| SCHEMBL27487140 | 0.84 | REN (0.65) | REN | |
| SCHEMBL27488919 | 0.84 | REN (0.60) | REN | |
| Bicarbonate SCHEMBL7547904 | 0.84 | REN (0.80) | REN | |
| SCHEMBL7160272 | 0.84 | REN (0.50) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1256326-C | Novel 4- (oxoxyphenyl) -3-oxopiperidines for the treatment of cardiac and renal insufficiency | HOFFMANN LA ROCHE (CH) | 2006-05-17 | — | — | CN | disclosed |
| US-6150526-A | Piperidine derivative having renin inhibiting activity | HOFFMANN-LA ROCHE INC. (US) | 2000-11-21 | — | — | US | disclosed |