Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL102433 | 0.84 | KDM4E (0.59) | KDM4EALDH1A1HPGDPOLBCYP1A2 | |
| SCHEMBL117700 | 0.83 | KDM4E (0.58) | KDM4EALDH1A1HPGDPOLBCYP1A2 | |
| SCHEMBL7274828 | 0.83 | KDM4E (0.58) | KDM4EALDH1A1HPGDPOLBCYP1A2 | |
| SCHEMBL9090050 | 0.83 | KDM4E (0.58) | KDM4EALDH1A1HPGDPOLBCYP1A2 | |
| SCHEMBL118201 | 0.82 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDPOLBCYP1A2 | |
| SCHEMBL8190856 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1HPGDPOLBCYP1A2 | |
| SCHEMBL1202722 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1HPGDPOLBCYP1A2 | |
| SCHEMBL118914 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1HPGDPOLBCYP1A2 | |
| SCHEMBL24857536 | 0.80 | KDM4E (0.54) | KDM4EALDH1A1HPGDPOLBCYP1A2 | |
| SCHEMBL8607273 | 0.80 | KDM4E (0.54) | KDM4EALDH1A1HPGDPOLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008082490-A2 | NOVEL JNK INHIBITORS | SCHERING CORPORATION (US) | 2008-07-10 | — | — | WO | disclosed |