Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8397630 | 0.87 | SIGMAR1 (0.50) | SIGMAR1HTR2AHTR2BCETPMEN1 | |
| SCHEMBL8332178 | 0.81 | SIGMAR1 (0.63) | SIGMAR1 | |
| SCHEMBL8198033 | 0.80 | SIGMAR1 (0.46) | SIGMAR1 | |
| SCHEMBL6719420 | 0.76 | SIGMAR1 (0.48) | SIGMAR1MEN1KMT2ACYP2D6CYP2C19 | |
| SCHEMBL6727687 | 0.76 | SIGMAR1 (0.51) | SIGMAR1LMNAMAPTHPGDMEN1 | |
| Hydrochloric Acid SCHEMBL7201876 | 0.75 | SIGMAR1 (0.49) | SIGMAR1CYP2D6CYP2C19CYP1A2 | |
| SCHEMBL27498292 | 0.73 | SIGMAR1 (0.64) | SIGMAR1 | |
| SCHEMBL8401133 | 0.72 | SIGMAR1 (0.40) | SIGMAR1MAPTCETPHPGDGAA | |
| SCHEMBL27482600 | 0.72 | SIGMAR1 (0.59) | SIGMAR1SLC6A4CYP2D6CYP3A4 | |
| SCHEMBL27519224 | 0.71 | SIGMAR1 (0.53) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156741-A | Therapeutic substituted guanidines | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-12-05 | — | — | US | claimed |