Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 11/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.47 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.47 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.47 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.47 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8194569 | 0.90 | NISCH (0.56) | NISCHALDH1A1CYP1A2HSD17B10CYP2D6 | |
| SCHEMBL6824770 | 0.90 | NISCH (0.60) | NISCHALDH1A1CYP1A2HSD17B10CYP2D6 | |
| Hydrochloric Acid SCHEMBL7735548 | 0.89 | NISCH (0.59) | NISCHALDH1A1CYP1A2HSD17B10CYP2D6 | |
| SCHEMBL8201878 | 0.87 | NISCH (0.51) | NISCHALDH1A1CYP1A2HSD17B10CYP2D6 | |
| SCHEMBL8202555 | 0.86 | NISCH (0.48) | NISCHALDH1A1CYP1A2HSD17B10CYP2D6 | |
| SCHEMBL8198114 | 0.85 | NISCH (0.54) | NISCHALDH1A1CYP1A2HSD17B10CYP2D6 | |
| SCHEMBL8200670 | 0.84 | NISCH (0.53) | NISCHALDH1A1CYP1A2HSD17B10CYP2D6 | |
| SCHEMBL8196630 | 0.84 | NISCH (0.53) | NISCHALDH1A1CYP1A2HSD17B10CYP2D6 | |
| SCHEMBL8188097 | 0.84 | NISCH (0.57) | NISCHALDH1A1CYP1A2HSD17B10CYP2D6 | |
| SCHEMBL8206599 | 0.83 | NISCH (0.55) | NISCHALDH1A1CYP1A2HSD17B10CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000078726-A1 | IMIDAZOLINE DERIVATIVES FOR THE TREATMENT OF DIABETES, ESPECIALLY TYPE II DIABETES | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |