Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Alanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.59 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.59 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.59 |
| ▸ | GABRP | O00591 | 2/20 | 0.46 |
| ▸ | GABRD | O14764 | 2/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.46 |
| ▸ | GABRE | P78334 | 2/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.46 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.46 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.46 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.46 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alanine SCHEMBL14677168 | 1.00 | GLRA1 (0.59) | GLRA1SLC6A9OR51E2GABRPGABRD | |
| D-Alanine SCHEMBL1537294 | 1.00 | GLRA1 (0.59) | GLRA1SLC6A9OR51E2GABRPGABRD | |
| Alanine SCHEMBL186137 | 1.00 | GLRA1 (0.59) | GLRA1SLC6A9OR51E2GABRPGABRD | |
| Alanine SCHEMBL6534719 | 1.00 | GLRA1 (0.59) | GLRA1SLC6A9OR51E2GABRPGABRD | |
| Alanine SCHEMBL17513685 | 1.00 | GLRA1 (0.59) | GLRA1SLC6A9OR51E2GABRPGABRD | |
| Alanine SCHEMBL1675385 | 1.00 | GLRA1 (0.59) | GLRA1SLC6A9OR51E2GABRPGABRD | |
| Alanine SCHEMBL25189736 | 1.00 | GLRA1 (0.59) | GLRA1SLC6A9OR51E2GABRPGABRD | |
| Alanine SCHEMBL2083490 | 1.00 | GLRA1 (0.59) | GLRA1SLC6A9OR51E2GABRPGABRD | |
| Alanine SCHEMBL8383645 | 1.00 | GLRA1 (0.59) | GLRA1SLC6A9OR51E2GABRPGABRD | |
| Alanine SCHEMBL157005 | 1.00 | GLRA1 (0.59) | GLRA1SLC6A9OR51E2GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 145 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022171101-A1 | STEROID CONJUGATE | 映恩生物制药（苏州）有限公司 | 2022-08-18 | — | — | WO | claimed |
| US-9932568-B2 | Peptide linkers for polypeptide compositions and methods for using same | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2018-04-03 | — | — | US | claimed |
| EP-3122902-A1 | METHOD OF PREDICTING THE TUMOR RESPONSE TO DNA METHYLATION INHIBITORS AND ALTERNATIVE THERAPEUTIC REGIMEN FOR OVERCOMING RESISTANCE | Palacký University In Olomouc (CZ) | 2017-02-01 | — | — | EP | claimed |
| US-20160152959-A1 | PEPTIDE LINKERS FOR POLYPEPTIDE COMPOSITIONS AND METHODS FOR USING SAME | SHIRE HUMAN GENETIC THERAPIES, INC. | 2016-06-02 | — | — | US | claimed |
| WO-2015144102-A1 | METHOD OF PREDICTING THE TUMOR RESPONSE TO DNA METHYLATION INHIBITORS AND ALTERNATIVE THERAPEUTIC REGIMEN FOR OVERCOMING RESISTANCE | PALACKY UNIVERSITY, OLOMOUC (CZ) | 2015-10-01 | — | — | WO | claimed |
| CN-103341587-A | Precoated sand and burn-free regeneration technology thereof | LINYI ZHUBAO WATER METER CO LTD | 2013-10-09 | — | — | CN | claimed |
| WO-2007124593-A1 | BRANCHED PEPTIDE AMPLIFICATION AND USES THEREOF | UNIVERSITE LAVAL (CA) | 2007-11-08 | — | — | WO | claimed |
| EP-1054677-A4 | COSMETIC OR DERMATOLOGICAL USE OF 7-HYDROXYLATED STEROIDS ALONE AND/OR IN COMBINATION WITH ELASTIN DERIVED PEPTIDES | MRS LLC (US) | 2005-07-27 | — | — | EP | claimed |
| EP-1064010-A4 | PEPTIDE COMPOSITIONS AND FORMULATIONS AND USE OF SAME | CONNECTIVE TISSUE IMAGINEERING (US) | 2004-10-06 | — | — | EP | claimed |
| EP-1064010-A1 | PEPTIDE COMPOSITIONS AND FORMULATIONS AND USE OF SAME | Mrs, Llc (US) | 2001-01-03 | — | — | EP | claimed |
| EP-1054677-A1 | COSMETIC OR DERMATOLOGICAL USE OF 7-HYDROXYLATED STEROIDS ALONE AND/OR IN COMBINATION WITH ELASTIN DERIVED PEPTIDES | Mrs, Llc (US) | 2000-11-29 | — | — | EP | claimed |
| WO-2000028996-A1 | COSMETIC OR DERMATOLOGICAL USE OF 7-HYDROXYLATED STEROIDS ALONE AND/OR IN COMBINATION WITH ELASTIN DERIVED PEPTIDES | MRS, LLC (US) | 2000-05-25 | — | — | WO | claimed |
| WO-1999045941-A1 | PEPTIDE COMPOSITIONS AND FORMULATIONS AND USE OF SAME | MRS, LLC (US) | 1999-09-16 | — | — | WO | claimed |
| EP-0504291-B1 | NOVEL PROTEINS WITH ONCOSTATIN M ACTIVITY AND PROCESS FOR THEIR PREPARATION | BRISTOL MYERS SQUIBB CO (US) | 1998-07-08 | — | — | EP | claimed |
| US-20240228977-A1 | GENERATION OF INDUCED PLURIPOTENT STEM CELLS FROM SMALL VOLUMES OF PERIPHERAL BLOOD | FUJIFILM Cellular Dynamics, Inc. (US) | 2024-07-11 | — | — | US | disclosed |
| CN-118201943-A | Anti-inflammatory compound and application thereof | 映恩生物制药（苏州）有限公司 | 2024-06-14 | — | — | CN | disclosed |
| EP-2582794-B2 | GENERATION OF INDUCED PLURIPOTENT STEM CELLS FROM SMALL VOLUMES OF PERIPHERAL BLOOD | FUJIFILM CELLULAR DYNAMICS INC (US) | 2024-04-24 | — | — | EP | disclosed |
| EP-0451612-A1 | Anti-oncostatin M monoclonal antibodies | Bristol-Myers Squibb Company (US) | 1991-10-16 | — | — | EP | disclosed |
| WO-1991009057-A1 | NOVEL PROTEINS WITH ONCOSTATIN M ACTIVITY AND PROCESS FOR THEIR PREPARATION | ONCOGEN LIMITED PARTNERSHIP (US) | 1991-06-27 | — | — | WO | disclosed |
| WO-1982000641-A1 | PEPTIDE SUBSTRATES FOR DETERMINATION OF PROTEASE ACTIVITY | KABIVITRUM AB (SE) | 1982-03-04 | — | — | WO | disclosed |