Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.74 |
| ▸ | ARG2 | P78540 | 4/20 | 0.47 |
| ▸ | ARG1 | P05089 | 3/20 | 0.47 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | GRM8 | O00222 | 1/20 | 0.45 |
| ▸ | GRM6 | O15303 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.45 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8199481 | 1.00 | GSR (0.74) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL28274437 | 1.00 | GSR (0.74) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL18153059 | 1.00 | GSR (0.74) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL21122146 | 0.94 | GSR (0.83) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL2821896 | 0.94 | GSR (0.83) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL1923415 | 0.94 | GSR (0.83) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL15283764 | 0.94 | GSR (0.83) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL23295178 | 0.92 | GSR (0.87) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL1000738 | 0.92 | GSR (0.87) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL999246 | 0.92 | GSR (0.87) | GSRARG2ARG1RNPEPCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6126945-A | Tumor killing effects of enterotoxins, superantigens, and related compounds | PHARMACIA AB (SE) | 2000-10-03 | — | — | US | disclosed |
| US-5728388-A | CONTACTING SAMPLE COMPRISING TUMOR-SENSITIZED CELLS WITH SUPERANTIGENS TO PRODUCE STIMULATED CELLS, INFUSING INTO TUMOR BEARING HOST | TERMAN DAVID S (US) | 1998-03-17 | — | — | US | disclosed |
| WO-1993024136-A1 | TUMOR KILLING EFFECTS OF ENTEROTOXINS, SUPERANTIGENS, AND RELATED COMPOUNDS | TERMAN DAVID S (US) | 1993-12-09 | — | — | WO | disclosed |