Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.87 |
| ▸ | ARG2 | P78540 | 4/20 | 0.53 |
| ▸ | ARG1 | P05089 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | GRM8 | O00222 | 1/20 | 0.52 |
| ▸ | GRM6 | O15303 | 1/20 | 0.52 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.52 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.52 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.52 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.52 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.52 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.52 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.52 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.52 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.52 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL209698 | 1.00 | GSR (0.87) | GSRARG2ARG1CYP1A2GRM8 | |
| Lysine SCHEMBL845918 | 1.00 | GSR (0.87) | GSRARG2ARG1CYP1A2GRM8 | |
| Lysine SCHEMBL209697 | 1.00 | GSR (0.87) | GSRARG2ARG1CYP1A2GRM8 | |
| Lysine SCHEMBL999246 | 1.00 | GSR (0.87) | GSRARG2ARG1CYP1A2GRM8 | |
| Lysine SCHEMBL377041 | 1.00 | GSR (0.87) | GSRARG2ARG1CYP1A2GRM8 | |
| Lysine SCHEMBL23295178 | 1.00 | GSR (0.87) | GSRARG2ARG1CYP1A2GRM8 | |
| Lysine SCHEMBL2182542 | 1.00 | GSR (0.87) | GSRARG2ARG1CYP1A2GRM8 | |
| Lysine SCHEMBL4583369 | 1.00 | GSR (0.87) | GSRARG2ARG1CYP1A2GRM8 | |
| Lysine SCHEMBL7082500 | 0.98 | GSR (0.83) | GSRARG2ARG1CYP1A2GRM8 | |
| Lysine SCHEMBL8950821 | 0.94 | GSR (0.77) | GSRARG2ARG1CYP1A2GRM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024140670-A1 | CONJUGATE AND USES THEREOF | FULL-LIFE TECHNOLOGIES HK LIMITED (CN) | 2024-07-04 | — | — | WO | claimed |
| US-20040254110-A1 | Methods for diagnosing and treating Alzheimer's disease | TRUSTEES OF BOSTON UNIVERSITY | 2004-12-16 | — | — | US | claimed |
| EP-1053008-B1 | METHODS OF INDUCING HAIR GROWTH AND COLORATION | UNIV BOSTON (US) | 2004-11-03 | — | — | EP | claimed |
| US-20020051988-A1 | Methods for diagnosing and treating alzheimer's disease | TRUSTEES OF BOSTON UNIVERSITY | 2002-05-02 | — | — | US | claimed |
| US-6242416-B1 | Inhibition of β-amyloid binding to the p75 nerve growth factor receptor | TRUSTEES OF BOSTON UNIVERSITY | 2001-06-05 | — | — | US | claimed |
| EP-1053008-A2 | METHODS OF INDUCING HAIR GROWTH AND COLORATION | TRUSTEES OF BOSTON UNIVERSITY (US) | 2000-11-22 | — | — | EP | claimed |
| WO-1999039728-A2 | METHODS OF INDUCING HAIR GROWTH AND COLORATION | TRUSTEES OF BOSTON UNIVERSITY (US) | 1999-08-12 | — | — | WO | claimed |
| US-4340592-A | OLICOPEPTIDES FOR DIETARY PURPOSES | ADIBI SIAMAK A | 1982-07-20 | — | — | US | claimed |
| WO-2024140670-A1 | CONJUGATE AND USES THEREOF | FULL-LIFE TECHNOLOGIES HK LIMITED (CN) | 2024-07-04 | — | — | WO | disclosed |
| WO-2024022237-A1 | THREE-ARM POLYETHYLENE GLYCOL DERIVATIVE CONTAINING AMINO ACID RESIDUES | 厦门赛诺邦格生物科技股份有限公司 | 2024-02-01 | — | — | WO | disclosed |
| US-20220105194-A1 | CONJUGATE COMPRISING LIGAND, SPACER, PEPTIDE LINKER, AND BIOMOLECULE | ASTELLAS PHARMA INC. (JP) | 2022-04-07 | — | — | US | disclosed |
| EP-3909606-A1 | COMPLEX COMPRISING LIGAND AND CEACAM5 ANTIBODY FAB FRAGMENT | Astellas Pharma Inc. (JP) | 2021-11-17 | — | — | EP | disclosed |
| EP-3909608-A1 | COMPLEX COMPRISING LIGAND, SPACER, PEPTIDE LINKER, AND BIOMOLECULE | Astellas Pharma Inc. (JP) | 2021-11-17 | — | — | EP | disclosed |
| WO-2020145227-A1 | COMPLEX COMPRISING LIGAND, SPACER, PEPTIDE LINKER, AND BIOMOLECULE | アステラス製薬株式会社 | 2020-07-16 | — | — | WO | disclosed |
| US-6242416-B1 | Inhibition of β-amyloid binding to the p75 nerve growth factor receptor | TRUSTEES OF BOSTON UNIVERSITY | 2001-06-05 | — | — | US | disclosed |
| US-6242416-B1 | Inhibition of β-amyloid binding to the p75 nerve growth factor receptor | TRUSTEES OF BOSTON UNIVERSITY | 2001-06-05 | — | — | US | disclosed |
| EP-1053008-A2 | METHODS OF INDUCING HAIR GROWTH AND COLORATION | TRUSTEES OF BOSTON UNIVERSITY (US) | 2000-11-22 | — | — | EP | disclosed |
| WO-1999039728-A2 | METHODS OF INDUCING HAIR GROWTH AND COLORATION | TRUSTEES OF BOSTON UNIVERSITY (US) | 1999-08-12 | — | — | WO | disclosed |
| EP-0890105-A1 | METHODS FOR DIAGNOSING AND TREATING ALZHEIMER'S DISEASE | BOSTON UNIVERSITY (US) | 1999-01-13 | — | — | EP | disclosed |
| WO-1997037228-A1 | METHODS FOR DIAGNOSING AND TREATING ALZHEIMER'S DISEASE | THE TRUSTEES OF BOSTON UNIVERSITY (US) | 1997-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220105194-A1 | CONJUGATE COMPRISING LIGAND, SPACER, PEPTIDE LINKER, AND BIOMOLECULE | MUC1, CA14, CA13 | GSR 4068/4885ARG2 2402/4885ARG1 1809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.