Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 9/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 8/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 6/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.44 |
| ▸ | DPP4 | P27487 | 6/20 | 0.43 |
| ▸ | FAP | Q12884 | 3/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8190780 | 1.00 | ADAM10 (0.51) | ADAM10MMP1ERBB2DPP8DPP7 | |
| Hydrochloric Acid SCHEMBL4406305 | 0.99 | ADAM10 (0.50) | ADAM10MMP1ERBB2DPP8DPP7 | |
| SCHEMBL2098678 | 0.92 | ADAM10 (0.49) | ADAM10MMP1ERBB2DPP8DPP7 | |
| SCHEMBL2098675 | 0.92 | ADAM10 (0.49) | ADAM10MMP1ERBB2DPP8DPP7 | |
| SCHEMBL7857753 | 0.92 | ADAM10 (0.49) | ADAM10MMP1ERBB2DPP8DPP7 | |
| SCHEMBL416579 | 0.92 | ADAM10 (0.49) | ADAM10MMP1ERBB2DPP8DPP7 | |
| SCHEMBL2098781 | 0.92 | ADAM10 (0.49) | ADAM10MMP1ERBB2DPP8DPP7 | |
| SCHEMBL8193679 | 0.88 | DPP8 (0.43) | ADAM10MMP1ERBB2DPP8DPP7 | |
| SCHEMBL8060188 | 0.88 | DPP8 (0.43) | ADAM10MMP1ERBB2DPP8DPP7 | |
| SCHEMBL8117948 | 0.87 | ADAM10 (0.41) | ADAM10MMP1ERBB2DPP8DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120716-A1 | MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS AND USES THEREFOR | PHENOMIX CORPORATION (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100120716-A1 | MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS AND USES THEREFOR | PHENOMIX CORPORATION (US) | 2010-05-13 | — | — | US | disclosed |
| WO-2009152051-A1 | SYNTHESIS OF A MACROCYCLIC HCV PROTEASE INHIBITOR | PHENOMIX CORPORATION (US) | 2009-12-17 | — | — | WO | disclosed |
| US-20090304631-A1 | HEPATITIS C SERINE PROTEASE INHIBITORS AND USES THEREFOR | PHENOMIX CORPORATION | 2009-12-10 | — | — | US | disclosed |
| US-20090304631-A1 | HEPATITIS C SERINE PROTEASE INHIBITORS AND USES THEREFOR | PHENOMIX CORPORATION | 2009-12-10 | — | — | US | disclosed |
| WO-2008070733-A2 | MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS AND USES THEREFOR | PHENOMIX CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |
| WO-2007089618-A2 | HEPATITIS C SERINE PROTEASE INHIBITORS AND USES THEREFOR | PHENOMIX CORPORATION (US) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090304631-A1 | HEPATITIS C SERINE PROTEASE INHIBITORS AND USES THEREFOR | PREP, CTSC, PEPD | ADAM10 121/4885MMP1 504/4885ERBB2 4763/4885 |
| US-20100120716-A1 | MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS AND USES THEREFOR | PREP, HPN, PEPD | ADAM10 161/4885MMP1 386/4885ERBB2 3883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.