SCHEMBL8199738

SCHEMBL8199738

CSCC[C@H](NC(=O)c1ccc(COCC(c2ccc(F)cc2)n2ccnc2)cc1-c1ccc(F)cc1)C(=O)NS(=O)(=O)c1ccc(Cl)cc1

nearest known ligand 0.42

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FNTA P49354 9/20 0.41
FNTB P49356 9/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7562579 0.86 FNTA (0.49) FNTAFNTB
SCHEMBL7562645 0.85 FNTA (0.42) FNTAFNTB
SCHEMBL7562658 0.80 FNTA (0.41) FNTAFNTB
SCHEMBL8185384 0.78 FNTA (0.38) FNTAFNTB
SCHEMBL7563888 0.77 FNTA (0.46) FNTAFNTB
SCHEMBL7703286 0.77 FNTA (0.39) FNTAFNTB
SCHEMBL7703285 0.77 FNTA (0.39) FNTAFNTB
SCHEMBL7568529 0.75 CYP17A1 (0.47)
SCHEMBL7565357 0.75 FNTA (0.44) FNTAFNTB
SCHEMBL7694133 0.74 FNTA (0.43) FNTAFNTB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1025088-A1 IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS AstraZeneca UK Limited (GB) 2000-08-09 EP claimed
WO-1999020611-A1 IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS ZENECA LIMITED (GB) 1999-04-29 WO claimed