SCHEMBL8200010

SCHEMBL8200010

NC1CCc2c(ccc3ccccc23)CC1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ANPEP P15144 5/20 0.64
IL1RN P18510 2/20 0.46
ERAP2 Q6P179 2/20 0.46
ERAP1 Q9NZ08 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8191935 0.88 ANPEP (0.73) ANPEPIL1RNERAP2ERAP1
SCHEMBL9513734 0.84 ANPEP (0.77) ANPEP
SCHEMBL9513876 0.78 ANPEP (1.00) ANPEPIL1RNERAP2ERAP1
SCHEMBL3478078 0.74 ANPEP (0.49) ANPEP
SCHEMBL1718547 0.73 ANPEP (1.00) ANPEPIL1RNERAP2ERAP1
SCHEMBL1718097 0.72 IL1RN (0.66) ANPEPIL1RNERAP2ERAP1
Hydrochloric Acid SCHEMBL3230097 0.72 ANPEP (1.00) ANPEPIL1RNERAP2ERAP1
SCHEMBL8713911 0.72 ANPEP (0.44) ANPEP
Hydrochloric Acid SCHEMBL3226375 0.71 IL1RN (0.64) ANPEPIL1RNERAP2ERAP1
Hydrochloric Acid SCHEMBL8717493 0.71 ANPEP (0.43) ANPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2084125-B1 AMINOBENZOCYCLOHEPTENE DERIVATIVES, METHODS FOR PREPARING THE SAME AND USES THEREOF IN THERAPY UNIV HAUTE ALSACE (FR) 2012-01-11 EP disclosed
US-20100069504-A1 AMINOBENZOCYCLOHEPTENE DERIVATIVES, METHODS FOR PREPARING THE SAME AND USES THEREOF IN THERAPY UNIVERSITE DE HAUTE ALSACE (FR) 2010-03-18 US disclosed
US-20100069504-A1 AMINOBENZOCYCLOHEPTENE DERIVATIVES, METHODS FOR PREPARING THE SAME AND USES THEREOF IN THERAPY UNIVERSITE DE HAUTE ALSACE (FR) 2010-03-18 US disclosed
WO-2008059141-A1 AMINOBENZOCYCLOHEPTENE DERIVATIVES, METHODS FOR PREPARING THE SAME AND USES THEREOF IN THERAPY UNIVERSITE DE HAUTE ALSACE (FR) 2008-05-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100069504-A1 AMINOBENZOCYCLOHEPTENE DERIVATIVES, METHODS FOR PREPARING THE SAME AND USES THEREOF IN THERAPY ANPEP, ENPEP, DNPEP ANPEP 1/4885IL1RN 985/4885ERAP2 17/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.