Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Alanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | GCLC | P48506 | 1/20 | 0.38 |
| ▸ | ENPEP | Q07075 | 3/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 2/20 | 0.37 |
| ▸ | GABRD | O14764 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alanine SCHEMBL2592623 | 0.86 | SLC7A5 (0.48) | SLC7A5TP53PMP22SLC1A3SLC1A2 | |
| Alanine SCHEMBL27873237 | 0.86 | SLC7A5 (0.48) | SLC7A5TP53PMP22SLC1A3SLC1A2 | |
| Alanine SCHEMBL2592625 | 0.86 | SLC7A5 (0.48) | SLC7A5TP53PMP22SLC1A3SLC1A2 | |
| Alanine SCHEMBL31150674 | 0.86 | SLC7A5 (0.48) | SLC7A5TP53PMP22SLC1A3SLC1A2 | |
| Alanine SCHEMBL17874433 | 0.83 | SLC7A5 (0.46) | SLC7A5TP53PMP22SLC1A3SLC1A2 | |
| Alanine SCHEMBL27282765 | 0.83 | SLC7A5 (0.46) | SLC7A5TP53PMP22SLC1A3SLC1A2 | |
| Alanine SCHEMBL17874434 | 0.83 | SLC7A5 (0.46) | SLC7A5TP53PMP22SLC1A3SLC1A2 | |
| Alanine SCHEMBL28212270 | 0.83 | CA1 (0.47) | SLC7A5TP53PMP22SLC1A3SLC1A2 | |
| Valine SCHEMBL28668412 | 0.83 | SLC7A5 (0.68) | SLC7A5TP53PMP22GCLCENPEP | |
| Valine SCHEMBL29084738 | 0.83 | SLC7A5 (0.68) | SLC7A5TP53PMP22GCLCENPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6140123-A | PREPARING TISSUES FOR STORAGE IN FREEZING CONDITIONS; SUSPENSION OF TISSUE IN AND FREEZING | CEDARS-SINAI MEDICAL CENTER (US) | 2000-10-31 | — | — | US | disclosed |