Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 6/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | GHSR | Q92847 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8200326 | 1.00 | GRIN1 (0.51) | GRIN1GRIN2BUSP2MAPTMAPK1 | |
| SCHEMBL8200332 | 1.00 | GRIN1 (0.51) | GRIN1GRIN2BUSP2MAPTMAPK1 | |
| SCHEMBL8191013 | 0.85 | USP2 (0.47) | GRIN1GRIN2BUSP2MAPTMAPK1 | |
| SCHEMBL8191008 | 0.85 | USP2 (0.47) | GRIN1GRIN2BUSP2MAPTMAPK1 | |
| SCHEMBL8191011 | 0.85 | USP2 (0.47) | GRIN1GRIN2BUSP2MAPTMAPK1 | |
| SCHEMBL8199357 | 0.78 | BACE1 (0.57) | GRIN1GRIN2BHRH3 | |
| SCHEMBL8199355 | 0.78 | BACE1 (0.57) | GRIN1GRIN2BHRH3 | |
| SCHEMBL8199358 | 0.78 | BACE1 (0.57) | GRIN1GRIN2BHRH3 | |
| SCHEMBL7701273 | 0.78 | SLC6A9 (0.60) | GRIN1GRIN2BUSP2MAPTMAPK1 | |
| SCHEMBL7703437 | 0.78 | SLC6A9 (0.60) | GRIN1GRIN2BUSP2MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998036749-A1 | TETRALONE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-27 | — | — | WO | claimed |
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |