Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8197666 | 0.84 | ADORA1 (0.48) | ADORA1BRD4MAPK1PDE5APDE3A | |
| SCHEMBL8193833 | 0.82 | ADORA1 (0.52) | ADORA1ADORA2AMAPK1MAPK14ALDH1A1 | |
| SCHEMBL8186528 | 0.81 | PDE3A (0.60) | ADORA1ADORA2AMAPK1MAPK14JAK2 | |
| SCHEMBL8809138 | 0.81 | ADORA1 (0.64) | ADORA1BRD4ADORA2AMAPK1MAPK14 | |
| SCHEMBL7658127 | 0.76 | ADORA1 (0.53) | ADORA1ADORA2AMAPK1MAPK14IGF1R | |
| SCHEMBL6824871 | 0.75 | NPC1 (0.38) | ADORA1BRD4ADORA2AALDH1A1 | |
| SCHEMBL7364069 | 0.74 | PDE1A (0.39) | ADORA1BRD4ADORA2AMAPK14ALDH1A1 | |
| SCHEMBL6822006 | 0.72 | ADORA1 (0.46) | ADORA1BRD4MAPK1IGF1R | |
| SCHEMBL7036909 | 0.71 | ADORA1 (0.43) | ADORA1BRD4ADORA2AMAPK1PDE5A | |
| SCHEMBL7371668 | 0.71 | ADORA2A (0.37) | ADORA1BRD4ADORA2AMAPK14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000024742-A1 | PYRAZOLOPYRIDINE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-04 | — | — | WO | disclosed |