Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367567 | 0.86 | MAT2A (0.33) | ADORA1CYP11B1CYP11B2 | |
| SCHEMBL7367166 | 0.82 | BRD4 (0.44) | HSD17B10LMNAKDM4ETDP1ADORA1 | |
| SCHEMBL7399130 | 0.80 | PDE3A (0.45) | HSD17B10LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7362751 | 0.80 | MAPK14 (0.42) | ADORA2AADORA1MAPK14 | |
| SCHEMBL7363632 | 0.79 | BMPR1B (0.37) | LMNAADORA1BRD4POLBMAPK14 | |
| SCHEMBL7365171 | 0.78 | BMPR1B (0.36) | CYP1A2KDM4EADORA1BRD4TSHR | |
| SCHEMBL7366115 | 0.77 | USP2 (0.35) | CYP1A2CYP3A4ADORA1CYP11B1FYN | |
| SCHEMBL7362732 | 0.75 | BMPR1B (0.37) | HSD17B10CYP1A2CYP3A4ADORA2AADORA1 | |
| SCHEMBL8200370 | 0.74 | ADORA1 (0.44) | ADORA2AADORA1ALDH1A1BRD4MAPK14 | |
| SCHEMBL7036702 | 0.74 | BMPR1B (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |