SCHEMBL820045

SCHEMBL820045

Cl[Si](Cc1ccccc1)(Cc1ccccc1)Cc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CALM1 P0DP23 1/20 0.45
CYP19A1 P11511 1/20 0.42
IDO1 P14902 3/20 0.42
TSHR P16473 4/20 0.41
ALDH1A1 P00352 3/20 0.41
LOXL2 Q9Y4K0 2/20 0.41
TP53 P04637 1/20 0.41
TRPA1 O75762 1/20 0.41
CYP3A4 P08684 2/20 0.40
MAPT P10636 1/20 0.40
SIGMAR1 Q99720 1/20 0.40
MAOB P27338 2/20 0.39
HPGD P15428 1/20 0.39
ALOX15 P16050 1/20 0.39
ALOX12 P18054 1/20 0.39
CASP1 P29466 1/20 0.39
HSD17B10 Q99714 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
F2 P00734 1/20 0.39
PLG P00747 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL242725 0.82 CALM1 (0.45) CALM1CYP19A1IDO1TSHRALDH1A1
SCHEMBL1550020 0.82 CALM1 (0.45) CALM1CYP19A1IDO1TSHRALDH1A1
SCHEMBL15301728 0.79 SMN1; SMN2 (0.37) CALM1CYP19A1IDO1TSHRALDH1A1
SCHEMBL15302704 0.79 SMN1; SMN2 (0.37) CALM1CYP19A1IDO1TSHRALDH1A1
SCHEMBL2098666 0.78 TP53 (0.43) CALM1CYP19A1IDO1TSHRALDH1A1
SCHEMBL122439 0.78 TP53 (0.43) CALM1CYP19A1IDO1TSHRALDH1A1
SCHEMBL22689574 0.76 CALM1 (0.39) CALM1CYP19A1IDO1TSHRALDH1A1
SCHEMBL10318779 0.76 CYP19A1 (0.43) CALM1CYP19A1IDO1TSHRALDH1A1
SCHEMBL11240991 0.75 CALM1 (0.50) CALM1CYP19A1IDO1TSHRALDH1A1
SCHEMBL1728429 0.75 CALM1 (0.50) CALM1CYP19A1IDO1TSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 367 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120025537-A Atomic oxygen-resistant polyether-ether-ketone material for aviation, preparation method thereof and composite material 南京工业大学 2025-05-23 CN claimed
CN-114249786-A Preparation and application of nucleoside intermediate containing N, N-diacyl structure 上海彩迩文生化科技有限公司 2022-03-29 CN claimed
CN-102911114-A Synthetic method for 3, 5-dibromo-4-iodopyridine catalyzed by alkyl silicon reagent UNIV XIHUA 2013-02-06 CN claimed
US-20080275241-A1 Polymorphic Forms of Dolasetron Base and Processes of Preparing Dolasetron Base, Its Polymorphic Forms and Salt Thereof USV LIMITED (IN) 2008-11-06 US claimed
WO-2007072507-A2 POLYMORPHIC FORMS OF DOLASETRON BASE AND PROCESSES OF PREPARING DOLASETRON BASE, ITS POLYMORPHIC FORMS AND SALT THEREOF USV LIMITED (IN) 2007-06-28 WO claimed
US-6365643-B1 Photoinitiators for cationic curing TH. GOLDSCHMIDT AG (DE) 2002-04-02 US claimed
US-5919552-A Coated substrates and methods XEROX CORPORATION (US) 1999-07-06 US claimed
EP-0067066-B2 Dry-developing resist composition FUJITSU LTD (JP) 1994-01-12 EP claimed
US-4614616-A Process for preparing 3β7β-dihydroxy-Δ5 -steroids SCHERING AKTIENGESELLSCHAFT (DE) 1986-09-30 US claimed
EP-0067066-B1 DRY-DEVELOPING RESIST COMPOSITION FUJITSU LIMITED (JP) 1985-12-18 EP claimed
EP-0067067-B1 DRY-DEVELOPING NEGATIVE RESIST COMPOSITION FUJITSU LIMITED (JP) 1985-09-25 EP claimed
US-4481366-A Process for the preparation of a trifluorovinylsilane, and fluorine-containing polymer and process for its preparation SAGAMI CHEMICAL RESEARCH CENTER (JP) 1984-11-06 US claimed
US-4481279-A Dry-developing resist composition FUJITSU LIMITED (JP) 1984-11-06 US claimed
EP-0119404-A1 Fluorine-containing polymer and process for its preparation SAGAMI CHEMICAL RESEARCH CENTER (JP) 1984-09-26 EP claimed
US-4464455-A Dry-developing negative resist composition FUJITSU LIMITED (JP) 1984-08-07 US claimed
EP-0051143-B1 PROCESS FOR THE PREPARATION OF 3-BETA, 7-BETA-DIHYDROXY-DELTA-5 STEROIDS SCHERING AKTIENGESELLSCHAFT (DE) 1984-07-04 EP claimed
US-4416985-A Process for preparing 3β,7β-dihydroxy-Δ5 -steroids SCHERING, AKTIENGESELLSCHAFT (DE) 1983-11-22 US claimed
EP-0067067-A2 Dry-developing negative resist composition FUJITSU LIMITED (JP) 1982-12-15 EP claimed
EP-0067066-A2 Dry-developing resist composition FUJITSU LIMITED (JP) 1982-12-15 EP claimed
EP-0051143-A1 Process for the preparation of 3-beta, 7-beta-dihydroxy-delta-5 steroids SCHERING AKTIENGESELLSCHAFT (DE) 1982-05-12 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080275241-A1 Polymorphic Forms of Dolasetron Base and Processes of Preparing Dolasetron Base, Its Polymorphic Forms and Salt Thereof CYP4A11, CYP3A43, VKORC1 CALM1 2960/4885CYP19A1 1406/4885IDO1 814/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.