Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR0B1 | P51843 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4246713 | 0.79 | NR0B1 (0.64) | NR0B1GAAPOLBCYP1A2CYP3A4 | |
| SCHEMBL28620615 | 0.73 | NR0B1 (0.69) | NR0B1GAAPOLBCYP1A2CYP3A4 | |
| SCHEMBL13399577 | 0.72 | HDAC8 (0.56) | GAAPOLBCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL10283637 | 0.72 | HDAC8 (0.56) | GAAPOLBCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL1405670 | 0.72 | HDAC8 (0.56) | GAAPOLBCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL18751777 | 0.72 | HDAC8 (0.56) | GAAPOLBCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL1226583 | 0.72 | HDAC8 (0.56) | GAAPOLBCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL25309402 | 0.70 | GAA (0.56) | GAAHDAC8 | |
| SCHEMBL4231457 | 0.70 | HDAC8 (0.47) | NR0B1GAAPOLBCYP1A2CYP3A4 | |
| SCHEMBL13563456 | 0.70 | GAA (0.56) | GAAHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1044204-A1 | PROCESS FOR THE PREPARATION OF ALPHA-OXOLACTAMS | Research Corporation Technologies, Inc (US) | 2000-10-18 | — | — | EP | disclosed |
| WO-1999033837-A1 | PROCESS FOR THE PREPARATION OF α-OXOLACTAMS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1999-07-08 | — | — | WO | disclosed |