SCHEMBL8200564

SCHEMBL8200564

CCCCCCCCCCCCCCCCCCC1CNCCNCCNCCNCCN1

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CXCR4 P61073 1/20 0.44
S1PR1 P21453 2/20 0.41
S1PR3 Q99500 2/20 0.41
GBA1 P04062 4/20 0.40
GLB1 P16278 4/20 0.39
GBA2 Q9HCG7 2/20 0.39
SPHK1 Q9NYA1 2/20 0.39
GUSB P08236 1/20 0.39
GNAO1 P09471 3/20 0.37
GNAI3 P08754 2/20 0.37
GNAI1 P63096 2/20 0.37
S1PR2 O95136 1/20 0.37
S1PR4 O95977 1/20 0.37
S1PR5 Q9H228 1/20 0.37
ALDH1A1 P00352 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9187514 1.00 CXCR4 (0.44) CXCR4S1PR1S1PR3GBA1GLB1
SCHEMBL3129740 0.98 S1PR1 (0.42) CXCR4S1PR1S1PR3GBA1GLB1
SCHEMBL9751519 0.98 S1PR1 (0.42) CXCR4S1PR1S1PR3GBA1GLB1
SCHEMBL28114318 0.98 S1PR1 (0.42) CXCR4S1PR1S1PR3GBA1GLB1
SCHEMBL10797222 0.98 S1PR1 (0.42) CXCR4S1PR1S1PR3GBA1GLB1
SCHEMBL17344117 0.98 CXCR4 (0.45) CXCR4S1PR1S1PR3GBA1GLB1
SCHEMBL15155327 0.98 S1PR1 (0.42) CXCR4S1PR1S1PR3GBA1GLB1
SCHEMBL11648543 0.98 S1PR1 (0.42) CXCR4S1PR1S1PR3GBA1GLB1
SCHEMBL21010237 0.96 CXCR4 (0.42) CXCR4S1PR1S1PR3GBA1GLB1
SCHEMBL1638947 0.96 CXCR4 (0.42) CXCR4S1PR1S1PR3GBA1GLB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6084093-A SUBSTITUTED 1,4,7,10,13-PENTAAZACYCLOPENTADECANE MACROCYCLIC LIGANDS; MANGANESE COMPLEXES OF THE LIGAND ARE MIMICS OF SUPEROXIDE DISMUTASE; USEFUL AS THERAPEUTIC AGENTS FOR INFLAMMATORY DISEASES G. D. SEARLE & CO. (US) 2000-07-04 US disclosed
US-5874421-A Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide G. D. SEARLE & CO. (US) 1999-02-23 US disclosed
EP-0598753-B1 MANGANESE COMPLEXES OF NITROGEN-CONTAINING MACROCYCLIC LIGANDS EFFECTIVE AS CATALYSTS FOR DISMUTATING SUPEROXIDE MONSANTO CO (US) 1998-03-18 EP disclosed
US-5637578-A AGENTS FOR INFLAMMATION, ISCHEMIC/REPERFUSION INJURY, STROKE, ATHEROSCLEROSIS, AND HYPERTENSION MONSANTO COMPANY 1997-06-10 US disclosed
US-5610293-A TREATMENT OF INFLAMMATORY DISEASES, ISCHEMIC/REPERFUSION INJURY, STROKE, ATHERSCLEROSIS, HYPERTENSION MONSANTO COMPANY (US) 1997-03-11 US disclosed
EP-0598753-A1 MANGANESE COMPLEXES OF NITROGEN-CONTAINING MACROCYCLIC LIGANDS EFFECTIVE AS CATALYSTS FOR DISMUTATING SUPEROXIDE MONSANTO COMPANY (US) 1994-06-01 EP disclosed
WO-1993002090-A1 MANGANESE COMPLEXES OF NITROGEN-CONTAINING MACROCYCLIC LIGANDS EFFECTIVE AS CATALYSTS FOR DISMUTATING SUPEROXIDE MONSANTO COMPANY (US) 1993-02-04 WO disclosed
EP-0524161-A1 Manganese complexes of nitrogen containing macrocyclic ligands effective as catalysts for dismutating superoxide MONSANTO COMPANY (US) 1993-01-20 EP disclosed