Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.51 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.51 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.51 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.51 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.51 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.51 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.51 |
| ▸ | GRIK4 | Q16099 | 2/20 | 0.51 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.51 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.46 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8203088 | 0.89 | GRIA1 (0.54) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8201019 | 0.89 | GRIA1 (0.52) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| Sulfuric Acid SCHEMBL8206134 | 0.85 | GRIA1 (0.50) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8201053 | 0.84 | GRIA1 (0.49) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8180885 | 0.82 | GRIA1 (0.76) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| Water SCHEMBL8136158 | 0.82 | GRIA1 (0.48) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL7354969 | 0.81 | GRIA1 (0.54) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| Hydrochloric Acid SCHEMBL8193639 | 0.80 | GRIA1 (0.43) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| Hydrochloric Acid SCHEMBL8205086 | 0.79 | GRIA1 (0.43) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8911878 | 0.77 | GRIA1 (0.53) | GRIA1GRIA2GRIA3GRIA4GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121264-A | GLUTAMATE RECEPTOR ANTAGONIST, AMPA RECEPTOR ANTAGONIST, NMDA-GLYCINE RECEPTOR ANTAGONIST, KAINIC ACID NEUROTOXICITY INHIBITOR, ANTIISCHEMIC AGENT, PSYCHOTROPIC AGENT | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-09-19 | — | — | US | disclosed |
| EP-0919554-A1 | IMIDAZOLE-SUBSTITUTED QUINOXALINEDIONE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1999-06-02 | — | — | EP | disclosed |