Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 5/20 | 0.54 |
| ▸ | GRIA2 | P42262 | 5/20 | 0.54 |
| ▸ | GRIA3 | P42263 | 5/20 | 0.54 |
| ▸ | GRIA4 | P48058 | 5/20 | 0.54 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.54 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.54 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.54 |
| ▸ | GRIK4 | Q16099 | 2/20 | 0.54 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.54 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.49 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8180885 | 0.85 | GRIA1 (0.76) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8203088 | 0.84 | GRIA1 (0.54) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8117590 | 0.83 | GRIA1 (0.55) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8201019 | 0.82 | GRIA1 (0.52) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL7352040 | 0.81 | SLC22A6 (0.74) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| Bromide SCHEMBL8201265 | 0.81 | GRIA1 (0.51) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8346010 | 0.80 | GRIA1 (0.55) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| Sulfuric Acid SCHEMBL8206134 | 0.80 | GRIA1 (0.50) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8201053 | 0.79 | GRIA1 (0.49) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8340533 | 0.79 | SLC22A6 (0.68) | GRIA1GRIA2GRIA3GRIA4GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON*S AND ALZHEIMER*S DISEASE | SCHERING AKTIENGESEELLSCHAFT (DE) | 2001-09-11 | — | — | US | disclosed |
| US-6057304-A | Quinoxaline-phosphonic acid derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |