Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 4/20 | 0.37 |
| ▸ | RPA1 | P27694 | 3/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8188387 | 0.85 | PTGS2 (0.49) | SMN1; SMN2PPP1CACHRNA7MALT1RPA1 | |
| SCHEMBL8234603 | 0.79 | CYP2C9 (0.40) | SMN1; SMN2PPP1CACHRNA7MALT1RPA1 | |
| SCHEMBL8234607 | 0.78 | CYP2C9 (0.41) | SMN1; SMN2PPP1CACHRNA7MALT1RPA1 | |
| SCHEMBL8218313 | 0.77 | PPP1CA (0.50) | SMN1; SMN2PPP1CACHRNA7MALT1RPA1 | |
| SCHEMBL8188245 | 0.77 | PTGS2 (0.44) | SMN1; SMN2CHRNA7MALT1PTGS2CA1 | |
| SCHEMBL8260353 | 0.75 | PTGS2 (0.43) | SMN1; SMN2CHRNA7MALT1PTGS2CA1 | |
| SCHEMBL7471309 | 0.71 | PTGS2 (0.57) | PTGS2PTGS1HDAC3HDAC4HDAC1 | |
| SCHEMBL9055803 | 0.70 | MEN1 (0.53) | SMN1; SMN2PPP1CACHRNA7MALT1RPA1 | |
| SCHEMBL25149362 | 0.68 | PTGS2 (0.68) | PTGS2PTGS1HDAC3HDAC4HDAC1 | |
| SCHEMBL9205418 | 0.68 | PTGS2 (0.52) | CHRNA7MALT1PTGS2PTGS1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018741-A2 | PYRAZOLE COMPOUNDS AS COX-2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-04-06 | — | — | WO | claimed |