SCHEMBL8201385

SCHEMBL8201385

N[C@H](C=O)Cc1ccc(I)cc1

nearest known ligand 0.55

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.41
CYP2D6 P10635 1/20 0.41
APEX1 P27695 1/20 0.40
PMP22 Q01453 1/20 0.40
TP53 P04637 1/20 0.39
TSHR P16473 1/20 0.39
CYP3A4 P08684 2/20 0.39
IDO1 P14902 2/20 0.39
DPP4 P27487 3/20 0.39
DPP7 Q9UHL4 1/20 0.37
MMP2 P08253 1/20 0.35
SLC6A4 P31645 1/20 0.34
SLC7A5 Q01650 1/20 0.33
APP P05067 1/20 0.33
SPHK2 Q9NRA0 2/20 0.33
SPHK1 Q9NYA1 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8455594 1.00 CYP1A2 (0.41) CYP1A2CYP2D6APEX1PMP22TP53
SCHEMBL24311641 1.00 CYP1A2 (0.41) CYP1A2CYP2D6APEX1PMP22TP53
SCHEMBL8855721 0.83 TSHR (0.39) TP53TSHRCYP3A4SLC6A4SLC7A5
SCHEMBL9498462 0.81 CYP3A4 (0.42) TP53TSHRCYP3A4SLC6A4SLC7A5
SCHEMBL6670843 0.81 HRH3 (0.48)
SCHEMBL2269394 0.81 CYP3A4 (0.42) TP53TSHRCYP3A4SLC6A4SLC7A5
SCHEMBL6670839 0.81 HRH3 (0.48)
SCHEMBL242931 0.81 CYP3A4 (0.42) TP53TSHRCYP3A4SLC6A4SLC7A5
SCHEMBL9503518 0.79 CA2 (0.41) TP53TSHRSLC6A4
SCHEMBL1972358 0.79 TAAR1 (0.40) CYP1A2TP53TSHRIDO1SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6127340-A ESPCECIALLY THROMBIN, IN WHICH THE P1-P2 NATURAL AMIDE LINKAGE IS REPLACED BY ANOTHER BOND; INHIBITING COAGULATION OF BLOOD IN A CONTAINER; TREATMENT OR PREVENTION OF THROMBOSIS TRIGEN LIMITED (GB) 2000-10-03 US claimed
EP-0910583-A1 THROMBIN INHIBITORS TRIGEN LIMITED (GB) 1999-04-28 EP claimed
WO-1998000443-A1 THROMBIN INHIBITORS TRIGEN LIMITED (GB) 1998-01-08 WO claimed
EP-0809650-A1 SERINE PROTEASE INHIBITORS ELLERMAN PHARMACEUTICALS LIMITED (GB) 1997-12-03 EP claimed
WO-1996025427-A1 SERINE PROTEASE INHIBITORS ELLERMAN PHARMACEUTICALS LIMITED (GB) 1996-08-22 WO claimed
EP-0118280-B1 ENZYME INHIBITION Aktiebolaget Hässle (SE) 1989-07-12 EP claimed
US-4818748-A HYPOTENSIVE AGENTS BAYER AKTIENGESELLSCHAFT (DE) 1989-04-04 US claimed
US-4772686-A ANTICOAGULANTS AKTIEBOLAGET HASSLE (SE) 1988-09-20 US claimed
EP-0236874-A2 Renin inhibitors, their production and use, as well as derivatives of amino acids and amino aldehydes BAYER AG (DE) 1987-09-16 EP claimed
US-4638047-A Enzyme inhibition AKTIEBOLAGET HASSLE (SE) 1987-01-20 US claimed
WO-1984003507-A1 ENZYME INHIBITION FERRING AB (SE) 1984-09-13 WO claimed
EP-0118280-A1 Enzyme inhibition Aktiebolaget Hässle (SE) 1984-09-12 EP claimed
US-20090068717-A1 In vivo incorporation of unnatural amino acids THE SCRIPPS RESEARCH INSTITUTE (US) 2009-03-12 US disclosed
US-6127340-A ESPCECIALLY THROMBIN, IN WHICH THE P1-P2 NATURAL AMIDE LINKAGE IS REPLACED BY ANOTHER BOND; INHIBITING COAGULATION OF BLOOD IN A CONTAINER; TREATMENT OR PREVENTION OF THROMBOSIS TRIGEN LIMITED (GB) 2000-10-03 US disclosed
EP-0910583-A1 THROMBIN INHIBITORS TRIGEN LIMITED (GB) 1999-04-28 EP disclosed
WO-1998000443-A1 THROMBIN INHIBITORS TRIGEN LIMITED (GB) 1998-01-08 WO disclosed
EP-0236874-A2 Renin inhibitors, their production and use, as well as derivatives of amino acids and amino aldehydes BAYER AG (DE) 1987-09-16 EP disclosed
US-4638047-A Enzyme inhibition AKTIEBOLAGET HASSLE (SE) 1987-01-20 US disclosed
WO-1984003507-A1 ENZYME INHIBITION FERRING AB (SE) 1984-09-13 WO disclosed
EP-0118280-A1 Enzyme inhibition Aktiebolaget Hässle (SE) 1984-09-12 EP disclosed