Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4980235 | 0.91 | POLB (0.60) | POLBNPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL4985473 | 0.84 | THRA (0.60) | ALDH1A1LMNASPHK1CA12CA1 | |
| SCHEMBL4980270 | 0.83 | KDM4E (0.58) | POLBNPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL14542726 | 0.82 | SRC (0.49) | POLBNPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL4099470 | 0.81 | NR1H4 (0.56) | POLBNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL10789340 | 0.81 | POLB (0.57) | POLBNPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL5447804 | 0.81 | POLB (0.57) | POLBNPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL4100570 | 0.80 | S1PR1 (0.51) | POLBSMN1; SMN2SPHK1MAPTMAPK1 | |
| SCHEMBL27639092 | 0.79 | CA12 (0.64) | POLBNPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL4100884 | 0.79 | S1PR1 (0.53) | POLBSPHK1MAPTTHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143791-A | NERVOUS SYSTEM DISORDERS | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-11-07 | — | — | US | disclosed |