Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | PTPRB | P23467 | 1/20 | 0.31 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13329286 | 0.79 | ALDH1A1 (0.39) | SMN1; SMN2MMEKMT2ACA1CA2 | |
| SCHEMBL8201275 | 0.77 | SMN1; SMN2 (0.36) | SMN1; SMN2MMEKMT2ACA1CA2 | |
| SCHEMBL9210893 | 0.77 | CA1 (0.50) | SMN1; SMN2GRIK1GRIK2MMEKMT2A | |
| SCHEMBL15363829 | 0.76 | ALDH1A1 (0.41) | SMN1; SMN2MMEKMT2ACA1CA2 | |
| SCHEMBL28356315 | 0.76 | TET2 (0.45) | SMN1; SMN2GRIK1GRIK2MMEKMT2A | |
| SCHEMBL8192827 | 0.75 | KMT2A (0.43) | SMN1; SMN2GRIK1GRIK2MMEKMT2A | |
| SCHEMBL8192831 | 0.75 | KMT2A (0.43) | SMN1; SMN2GRIK1GRIK2MMEKMT2A | |
| SCHEMBL2098816 | 0.73 | ALDH1A1 (0.43) | SMN1; SMN2MMEKMT2ACA1CA2 | |
| SCHEMBL6442162 | 0.73 | TSHR (0.46) | SMN1; SMN2MMEKMT2ACA1CA2 | |
| SCHEMBL28674447 | 0.73 | SMN1; SMN2 (0.36) | SMN1; SMN2MMEKMT2ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882138-B1 | STEREOSELECTIVE PREPARATION OF 2-SUBSTITUTED SUCCINIC DERIVATIVES | BOEHRINGER INGELHEIM CA LTD (CA) | 2000-07-05 | — | — | EP | disclosed |
| EP-0882138-A1 | STEREOSELECTIVE PREPARATION OF 2-SUBSTITUTED SUCCINIC DERIVATIVES | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 1998-12-09 | — | — | EP | disclosed |
| US-5808085-A | CHEMICAL INTERMEDIATES FOR RENIN INHIBITING COMPOUNDS | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 1998-09-15 | — | — | US | disclosed |
| WO-1997023641-A1 | STEREOSELECTIVE PREPARATION OF 2-SUBSTITUTED SUCCINIC DERIVATIVES | BOEHRINGER INGELHEIM (CANADA) LTD./BOEHRINGER INGELHEIM (CANADA) LTÉE (CA) | 1997-07-03 | — | — | WO | disclosed |