Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 6/20 | 0.39 |
| ▸ | MLNR | O43193 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.35 |
| ▸ | TACR2 | P21452 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.34 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8209807 | 0.90 | GRM2 (0.39) | GRM2MLNRAGTR1TACR2TACR1 | |
| SCHEMBL3068893 | 0.81 | GRM2 (0.44) | GRM2TACR2TACR1 | |
| SCHEMBL3067246 | 0.81 | ITGB1 (0.43) | GRM2TACR2TACR1 | |
| SCHEMBL3068774 | 0.80 | GRM2 (0.47) | GRM2MLNRAGTR1TACR2TACR1 | |
| SCHEMBL3081725 | 0.80 | GRM2 (0.47) | GRM2TACR2TACR1 | |
| SCHEMBL3070726 | 0.79 | CXCR4 (0.43) | GRM2MLNRTACR2TACR1 | |
| SCHEMBL3057908 | 0.78 | GRM2 (0.53) | GRM2TACR2TACR1 | |
| SCHEMBL3068599 | 0.77 | GRM2 (0.49) | GRM2MLNRTACR2TACR1CYP3A4 | |
| SCHEMBL3073111 | 0.77 | GRM2 (0.50) | GRM2TACR2TACR1 | |
| SCHEMBL8210112 | 0.75 | GRM2 (0.45) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032191-A2 | SPIRO-OXAZOLIDINONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (US) | 2008-03-20 | — | — | WO | disclosed |