Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 7/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.55 |
| ▸ | HTR2A | P28223 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30678164 | 0.81 | MPO (0.65) | MPOSLC6A4HTR2AMAPTSMN1; SMN2 | |
| SCHEMBL2536475 | 0.81 | MPO (0.65) | MPOSLC6A4HTR2AMAPTSMN1; SMN2 | |
| SCHEMBL2536517 | 0.77 | HTR2A (0.62) | MPOSLC6A4HTR2AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL21546026 | 0.76 | HTR2A (0.60) | MPOSLC6A4HTR2AMAPTSMN1; SMN2 | |
| SCHEMBL8202667 | 0.76 | MPO (0.58) | MPOSLC6A4HTR2AMAPTSMN1; SMN2 | |
| SCHEMBL1968447 | 0.71 | MPO (1.00) | MPOSLC6A4HTR2AMAPTSMN1; SMN2 | |
| SCHEMBL2535339 | 0.71 | MPO (0.56) | MPOSLC6A4HTR2AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL23091149 | 0.70 | MPO (0.97) | MPOSLC6A4HTR2AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL21546063 | 0.70 | MPO (0.54) | MPOSLC6A4HTR2AMAPTSMN1; SMN2 | |
| SCHEMBL7818210 | 0.68 | HTR2A (0.62) | MPOSLC6A4HTR2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090945-A | HIGH AFFINITY FOR THE 5-HT1C RECEPTOR. | ELI LILLY AND COMPANY (US) | 2000-07-18 | — | — | US | disclosed |
| US-5760051-A | CENTRAL NERVOUS SYSTEM | ELI LILLY AND COMPANY (US) | 1998-06-02 | — | — | US | disclosed |
| US-5635528-A | RECEPTOR BINDING MODULATORS, FOR CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1997-06-03 | — | — | US | disclosed |
| US-5508284-A | TREATING 5-HYDROXYTRYPTAMINE MODULATION | ELI LILLY AND COMPANY (US) | 1996-04-16 | — | — | US | disclosed |
| US-5500431-A | ANTISEROTONINE AGENTS; SEXUAL AND EATING DISORDERS | ELI LILLY AND COMPANY (US) | 1996-03-19 | — | — | US | disclosed |
| WO-1994023720-A1 | TETRAHYDRO-BETA-CARBOLINES | ELI LILLY AND COMPANY (US) | 1994-10-27 | — | — | WO | disclosed |
| EP-0620222-A2 | Tetrahydro-beta-carbolines | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |