Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 19/20 | 0.77 |
| ▸ | MMP13 | P45452 | 16/20 | 0.77 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4011581 | 0.87 | MMP12 (1.00) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL31490335 | 0.87 | MMP12 (1.00) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL4010193 | 0.84 | MMP12 (0.94) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL4010948 | 0.82 | MMP12 (1.00) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL31490236 | 0.82 | MMP12 (1.00) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL4008618 | 0.72 | MMP12 (1.00) | MMP12MMP13 | |
| SCHEMBL31490328 | 0.72 | MMP12 (1.00) | MMP12MMP13 | |
| SCHEMBL8200620 | 0.72 | MMP12 (0.69) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL4921458 | 0.70 | NPC1 (0.67) | MMP12MMP13CA12CA1CA2 | |
| SCHEMBL14465082 | 0.69 | CA12 (0.58) | MMP12MMP13CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008057254-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH (US) | 2008-05-15 | — | — | WO | disclosed |