Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.48 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.48 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | ANPEP | P15144 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | LAP3 | P28838 | 1/20 | 0.47 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.47 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.47 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 3/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27784577 | 1.00 | MEN1 (0.50) | MEN1KMT2ATPSAB1TPSD1TPSG1 | |
| SCHEMBL1491678 | 0.84 | EPHX1 (0.46) | MEN1KMT2AMMP2MMP9ANPEP | |
| SCHEMBL1491681 | 0.84 | EPHX1 (0.46) | MEN1KMT2AMMP2MMP9ANPEP | |
| SCHEMBL1491449 | 0.82 | KLKB1 (0.49) | TPSAB1TPSD1TPSG1F2PRSS1 | |
| SCHEMBL1491446 | 0.82 | KLKB1 (0.49) | TPSAB1TPSD1TPSG1F2PRSS1 | |
| SCHEMBL2279040 | 0.81 | MEN1 (0.54) | MEN1KMT2AMMP2MMP9ANPEP | |
| SCHEMBL19236566 | 0.81 | SMN1; SMN2 (0.47) | MEN1KMT2AMMP2MMP9ANPEP | |
| SCHEMBL1491603 | 0.79 | MEN1 (0.55) | MEN1KMT2AMMP2MMP9ANPEP | |
| SCHEMBL1491605 | 0.79 | MEN1 (0.55) | MEN1KMT2AMMP2MMP9ANPEP | |
| SCHEMBL1491510 | 0.79 | MEN1 (0.48) | MEN1KMT2ATPSAB1TPSD1TPSG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962825-B2 | Hydroxamates as inhibitors of histone deacetylase | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2015-02-24 | — | — | US | disclosed |
| US-8962825-B2 | Hydroxamates as inhibitors of histone deacetylase | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2015-02-24 | — | — | US | disclosed |
| EP-2077999-B1 | HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | CHROMA THERAPEUTICS LTD (GB) | 2014-07-30 | — | — | EP | disclosed |
| CN-101553475-B | Hydroxamic acids as inhibitors of histone deacetylase | CHROMA THERAPEUTICS LTD | 2013-04-24 | — | — | CN | disclosed |
| US-20100317678-A1 | HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | CHROMA THERAPEUTICS LTD. (GB) | 2010-12-16 | — | — | US | disclosed |
| US-20100317678-A1 | HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | CHROMA THERAPEUTICS LTD. (GB) | 2010-12-16 | — | — | US | disclosed |
| CN-101553475-A | Hydroxamic acids as inhibitors of histone deacetylase | CHROMA THERAPEUTICS LTD (GB) | 2009-10-07 | — | — | CN | disclosed |
| WO-2008053131-A1 | HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317678-A1 | HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | H1-2, HDAC1, H1-0 | MEN1 1608/4885KMT2A 92/4885TPSAB1 1248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.