Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 4/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8204490 | 0.84 | HDAC6 (0.37) | DGAT2HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL3772993 | 0.84 | HDAC1 (0.45) | DGAT2HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL3773002 | 0.84 | HDAC1 (0.45) | DGAT2HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL8205770 | 0.82 | DGAT2 (0.43) | DGAT2HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL3780797 | 0.78 | HDAC3 (0.50) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL8194298 | 0.76 | DGAT2 (0.35) | DGAT2HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL8203640 | 0.76 | DGAT2 (0.39) | DGAT2HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL15906826 | 0.74 | HDAC6 (0.44) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL13007259 | 0.74 | HDAC6 (0.46) | DGAT2HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL13007264 | 0.72 | HDAC6 (0.49) | HDAC6HDAC1HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008053131-A1 | HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-08 | — | — | WO | disclosed |